ArticleCommunications biology2023
Arousal state transitions occlude sensory-evoked neurovascular coupling in neonatal mice.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 11 citations in OpenAlex.
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- 7 Tesla fMRI characterisation of the cortical-depth-dependent BOLD response in early human development.bioRxiv : the preprint server for biology · 2025Article
- Type-I nNOS neurons orchestrate cortical neural activity and vasomotion.bioRxiv : the preprint server for biology · 2025Article
- Cerebral blood flow and energy demand: imaging insights into neurovascular function.Neurophotonics · 2025Review
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- Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.Trends in neurosciences · 2025Review
- Arousal state transitions occlude sensory-evoked neurovascular coupling in neonatal mice.Communications biology · 2023Article
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7 authors at 1 institution in 2 countries.
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Abstract
In the adult sensory cortex, increases in neural activity elicited by sensory stimulation usually drive vasodilation mediated by neurovascular coupling. However, whether neurovascular coupling is the same in neonatal animals as adults is controversial, as both canonical and inverted responses have been observed. We investigated the nature of neurovascular coupling in unanesthetized neonatal mice using optical imaging, electrophysiology, and BOLD fMRI. We find in neonatal (postnatal day 15, P15) mice, sensory stimulation induces a small increase in blood volume/BOLD signal, often followed by a large decrease in blood volume. An examination of arousal state of the mice revealed that neonatal mice were asleep a substantial fraction of the time, and that stimulation caused the animal to awaken. As cortical blood volume is much higher during REM and NREM sleep than the awake state, awakening occludes any sensory-evoked neurovascular coupling. When neonatal mice are stimulated during an awake period, they showed relatively normal (but slowed) neurovascular coupling, showing that that the typically observed constriction is due to arousal state changes. These result show that sleep-related vascular changes dominate over any sensory-evoked changes, and hemodynamic measures need to be considered in the context of arousal state changes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.