Evolution from Medical Imaging to Visualized Medicine.

The discovery of X-ray in 1895 and the first X-ray image of Mrs. Röntgen's hand opened up a new era of radiology and the research of medical imaging. The evolution of traditional medical imaging has been lasting for over 100 years, serving the detection, diagnosis, and treatments of human diseases with a clear view of the anatomy information. In late 1990s, the concept of molecular imaging was proposed as the science and technology of molecular biology and bio-engineering rapidly developed, and it directly gave birth to the emergence of precision medicine for clinical lesion-targeted treatments against various cancers and cardiocerebrovascular diseases. Physiological and pathological changes in live bodies from zebrafish to human beings can be imaged to ensure an efficient image-guided therapy. Nowadays, the philosophy of medical and molecular imaging has been a powerful tool and indispensable modality for doctors to make their decisions and give patients reliable advices. With the ever-emerging developments of advanced intelligent technologies such as flexible sensors, medical meta-data analysis, brain sciences, surgical robots, VR/AR, etc., modern medicine has been evolving from traditional medical and molecular imaging to visualized medicine, which has created novel accessible approaches along with cutting-edge techniques for the revolutionized diagnostic and therapeutic paradigms. In this context, the history and milestones from medical imaging to visualized medicine will be elucidated. And in particular, representative visualized medicine advances including its application to COVID-19 epidemics will be discussed in order to look for its important contributions and a future perspective to modern medicine.