ArticlePediatric research2023
The association of placental pathology and neurodevelopmental outcomes in patients with neonatal encephalopathy.
Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Chorioamnionitis and Two-Year Outcomes in Infants with Hypoxic-Ischemic Encephalopathy.The Journal of pediatrics · 2025Trial
- Maternal-placental timing profiles of hypoxic-ischemic insult and association with prognosis in neonatal encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Nonlinear dose-response of umbilical cord blood IL-6 to severe brain injury in preterm infants: a prospective cohort study.Pediatric research · 2026Article
- Optimizing neonatal management in the prescence of intrapartum maternal fever via the integration of an early-onset sepsis risk calculator and dynamic inflammatory markers.Frontiers in pediatrics · 2026Article
- Emerging modalities for neuroprognostication in neonatal encephalopathy: harnessing the potential of artificial intelligence.Pediatric research · 2025Review
- Placental histology for infants with hypoxic ischaemic encephalopathy compared with healthy controls: a case-control study.BMC pediatrics · 2025Article
- Lipopolysaccharide Sensitizes Steroid-Induced Brain Injury in Neonatal Rat Pups.Mediators of inflammation · 2025Article
- Case Report: Congenital hepatic hemangioma with arteriovenous fistula: 2-year multidisciplinary management and outcomes.Frontiers in pediatrics · 2025Article
- Placental histology, perioperative brain development, and neurodevelopmental outcome at 1 year of age in patients undergoing neonatal cardiac surgery-is there an association?Frontiers in cardiovascular medicine · 2025Article
- Understanding the role of the placenta in neonatal encephalopathy and outcome.Pediatric research · 2024Article
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6 authors at 3 institutions in 1 country.
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Abstract
backgroundStudies conflict on how acute versus chronic placental pathology impacts outcomes after neonatal encephalopathy from presumed hypoxic-ischemic encephalopathy (HIE). We examine how outcomes after presumed HIE vary by placental pathology categories.
methodsWe performed retrospective chart review for neonates with presumed HIE, regardless of severity, focusing on 50 triads for whom placental specimens were available for re-review. Placentas were categorized as having only acute, any chronic, or no lesions. Primary outcomes included in-hospital morbidity/mortality and long-term neurodevelopmental symptoms. Secondary outcomes assessed neonatal MRI and EEG.
resultsDemographics did not differ between groups. Forty-seven neonates were treated with therapeutic hypothermia. Placental acuity category was not associated with primary or secondary outcomes, but clinical and/or histopathological chorioamnionitis was associated with abnormal EEG background and post-neonatal epilepsy (16.7%, n = 3 with chorioamnionitis versus 0%, n = 0 without chorioamnionitis, p = 0.04).
conclusionsWhen grouped by acute, chronic, or absent placental lesions, we observed no association with in-hospital, neurodevelopmental, MRI, or EEG outcomes. When reanalyzed by the presence of chorioamnionitis, we found that chorioamnionitis appeared to be associated with a higher risk of EEG alterations and post-neonatal epilepsy. Despite our limited sample size, our results emphasize the critical role of placental examination for neuroprognostication in presumed HIE. IMPACT: Neonatal encephalopathy presumed to result from impaired fetal cerebral oxygenation or blood flow is called hypoxic ischemic encephalopathy (HIE). Prior studies link placental pathology to various outcomes after HIE but disagree on the impact of acute versus chronic pathology. Our study determines that neurodevelopmental outcomes, in-hospital outcomes, injury on MRI, and EEG findings in patients with HIE are not differentially associated with acute versus chronic placental pathology. Chorioamnionitis is associated with an increased risk of abnormal EEG patterns and post-neonatal epilepsy. Histopathologic chorioamnionitis without clinical symptoms is common in HIE, emphasizing the crucial role of placental pathology for neuroprognostication.
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