ReviewCell death and differentiation2023
Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions.
Abstract readReview
In one paragraph
Review in Cell death and differentiation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 263 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
263citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
263 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Pooled it
- Ionomycin enhances radiosensitivity in breast cancer through reactive oxygen species generation and mitochondrial permeability transition pore opening.Medical gas research · 2026Article
- Pharmacological activation of SIRT1 alleviates sepsis-associated acute kidney injury by improving renal mitochondrial energy metabolism.Renal failure · 2026Article
- Mitochondrial dysfunction‑driven ferroptosis in cerebral ischemia‑reperfusion injury: Mechanisms and therapeutic strategies (Review).Molecular medicine reports · 2026Review
- Metformin Inhibits Ferroptotic Cell Death by Suppressing Cysteine Deprivation-Induced Mitochondrial Dysfunction.Pharmacology research & perspectives · 2026Article
- Mitochondria-associated endoplasmic reticulum membranes and calcium ion exchange: A novel direction for aging and neurodegenerative diseases.Neural regeneration research · 2026Article
- ROS scavenging mitigates TNFα-induced endoplasmic reticulum stress and mitochondrial fragmentation in human airway smooth muscle.Function (Oxford, England) · 2026Article
- Context-Dependent modulation of astrocytic CaJournal of computational neuroscience · 2026Article
- Disturbances of Mitochondrial Functions and Oxidative Stress Induction in Methylmalonic and Propionic Acidemias: A Critical Role for Metabolite Accumulation.International journal of molecular sciences · 2026Review
- ATP synthase subunits e and g are essential for CaCell death and differentiation · 2026Article
- Acute Heat Stress Remodels Mitochondrial Ultrastructure and Time-Dependent Transcriptomic Landscapes in Bovine Granulosa Cells.Animals : an open access journal from MDPI · 2026Article
- Structure-Based Screening Identifies Polyphenol Glucuronides as Cyclophilin D Ligands.Molecules (Basel, Switzerland) · 2026Article
- Role of voltage-dependent anion channel 1 in neurodegeneration: Mechanisms, implications, and therapeutic potential.Neural regeneration research · 2026Article
- Preserved mitochondrial respiration in presence of oxidative stress and reduced mitochondrial mass after 10-day bed rest in older adults.The Journal of physiology · 2026Article
- Review
- Age-Associated NAD+ Decline and Mitochondrial Dysfunction Predispose Cells to a Reversible Tumor-Permissive Metabolic State.Biology · 2026Article
- Comparative Study of the Cytotoxic Effects of Outer Membrane Vesicles fromPathogens (Basel, Switzerland) · 2026Article
- Mitochondrial Permeability Transition Regulators As Emerging Therapeutic Targets in Aging and Neurodegeneration: Recent Insights.Journal of molecular neuroscience : MN · 2026Review
- Mitochondrial vulnerability to aldehydic load and the role mitochondrial aldehyde dehydrogenases.Pharmacological research · 2026Review
- Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia-reperfusion injury.The Journal of physiology · 2026Review
203 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Paolo BernardiDepartment of Biomedical Sciences, University of Padova, Padova, Italy.ORCID 0000-0001-9187-3736
Christoph GerleLaboratory of Protein Crystallography, Institute for Protein Research, Osaka University, Suita, Japan.ORCID 0000-0002-7265-2804
Andrew P HalestrapSchool of Biochemistry and Bristol Heart Institute, University of Bristol, Bristol, UK.ORCID 0000-0001-5374-2778
Elizabeth A JonasDepartment of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1624-5999
Jason KarchDepartment of Integrative Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Nelli MnatsakanyanDepartment of Cellular and Molecular Physiology, College of Medicine, Penn State University, State College, PA, USA.ORCID 0000-0001-5363-7409
Evgeny PavlovDepartment of Molecular Pathobiology, New York University, New York, NY, USA.
Shey-Shing SheuDepartment of Medicine, Center for Translational Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA. shey-shing.sheu@jefferson.edu.ORCID 0000-0003-3838-3601
Alexander A SoukasDepartment of Medicine, Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6MP&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Aaron S Leong · 2023 to 2026
$5.4MCa2+ and ROS Crosstalk Signaling in Cardiac MitochondriaR01HL093671 · NHLBI · UNIVERSITY OF ROCHESTER · PI SHEU, SHEY-SHING · 2010 to 2023
$5.1MMitochondrial Ion Channels in Hypoxic NeuronsR37NS045876 · NINDS · YALE UNIVERSITY · PI Elizabeth Ann Jonas · 2014 to 2026
$4.9MMitochondria-SR Tethering: Its Role in Cardiac Bioenergetics and Ca2+ DynamicsR01HL122124 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CSORDAS, GYORGY, SHEU, SHEY-SHING · 2014 to 2025
$4.0MGenetic mechanisms of metformin's pro-longevity and anti-cancer effectsR01AG058256 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SOUKAS, ALEXANDER A · 2018 to 2022
$3.0MMolecular Regulation of Mitochondrial Permeability Transition and its Role in Regulated NecrosisR01HL150031 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Jason Michael Karch · 2020 to 2026
$2.9MDynamin-Related Protein Drp1 Regulates Cardiac Excitation-Contraction-Bioenergetics CouplingR01HL137266 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI SHEU, SHEY-SHING, WANG, WANG · 2018 to 2021
$2.5MStructural-functional zoning of the mitochondrion in cardiac Ca2+, ROS, and energetics regulationR01HL142864 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CSORDAS, GYORGY, SHEU, SHEY-SHING · 2018 to 2021
$2.5MMolecular mechanisms of the mitochondrial permeability transitionR35GM139615 · NIGMS · NEW YORK UNIVERSITY · PI PAVLOV, EVGENY · 2021 to 2025
$2.3MMitochondrial action of metformin in aging and longevityR01AG069677 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SOUKAS, ALEXANDER A · 2020 to 2024
$2.1MStructural and functional characterization of ATP synthase c-subunit leak channel and its role in AD pathogenesisRF1AG072484 · NIA · YALE UNIVERSITY · PI MNATSAKANYAN, NELLI · 2021 to 2021
$2.0MNHLBI NIH HHS R01 HL093671NHLBI NIH HHS R01 HL137266NHLBI NIH HHS R01 HL150031NIA NIH HHS K01 AG054734NIA NIH HHS R01 AG058256NIA NIH HHS R01 AG069677NIA NIH HHS R01 AG072484NIA NIH HHS R56 AG068999NIA NIH HHS R56 AG078384NIA NIH HHS RF1 AG072484NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK135043NIGMS NIH HHS R35 GM139615NINDS NIH HHS R37 NS045876
Abstract
The mitochondrial permeability transition (mPT) describes a Ca
Indexed as
Mitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreConsensusMitochondriaMitochondrial MembranesMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition Pore
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.