ArticleTranslational psychiatry2023
Altered brain dynamic in major depressive disorder: state and trait features.
Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Neurochemically informed network control theory reveals energetic dysregulation of altered brain state dynamics in obsessive-compulsive disorder.Psychiatry and clinical neurosciences · 2026Article
- Cortical neuron classes and recursive curvature collapse: a neurobiological model of conscious dynamics.Theory in biosciences = Theorie in den Biowissenschaften · 2026Article
- Exploring Neurofunctional Phase Transition Patterns in Autism Spectrum Disorder via Thermodynamics Parameters.Entropy (Basel, Switzerland) · 2026Article
- Insomnia severity impact dynamic connectivity and modulate connectivity-cognitive links in major depressive disorder.Psychological medicine · 2026Article
- Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity.Nature communications · 2026Article
- The association between spatiotemporal coupling of default mode network and behaviors is specifically modulated by peripheral inflammation in major depressive disorder.BMC psychiatry · 2026Article
- Brain energetic landscapes shape state dysregulation in major depressive disorder: a morphological network controllability perspective.Translational psychiatry · 2026Article
- Remodeling of the ventral attention network-default mode network as potential neural correlates of anxiety in lumbar disc herniation patients treated with lever positioning manipulation: a resting-state fMRI study.BMC complementary medicine and therapies · 2026Article
- Unveiling state-specific neural dynamics in migraine with and without depressive symptom: a hidden Markov model and interpretable machine learning approach.The journal of headache and pain · 2026Article
- Dynamic Functional Connectivity, Major Depression, and Suicidal Ideation in Children.Human brain mapping · 2026Article
- fNIRS-Based characterization of adolescent depression using dynamic functional connectivity biomarkers in a verbal fluency task.BMC psychiatry · 2026Article
- A Study on dynamic functional connectivity and efficacy prediction of SAINT for rapid antidepressant effects and relief of suicidal ideation.Translational psychiatry · 2025Article
- Same movies, different stories: aberrant brain state dynamics during naturalistic emotional stimuli in depression.Journal of translational medicine · 2025Article
- Unveiling the Multifaceted Networks of the Left DLPFC for Precision TMS Targeting.bioRxiv : the preprint server for biology · 2025Article
- Dynamic changes in hemispheric lateralization in major depressive disorder correlate with neurotransmitter and genetic profiles: a DIRECT consortium study.Translational psychiatry · 2025Article
- Ambulatory physiological state dynamics predict proximal behavioral markers of affect regulation in everyday life.Journal of psychopathology and clinical science · 2025Article
- Exploratory GABAa-informed control network modulates hyperarousal brain dynamics in chronic insomnia.Communications biology · 2025Article
- Functional brain network dynamics of brooding in depression: Insights from real-time fMRI neurofeedback.Journal of affective disorders · 2025Article
- The balance between integration and segregation drives network dynamics maximizing multistability and metastability.Scientific reports · 2025Article
- Transition and dynamic reconfiguration in late-life depression based on hidden Markov model.Npj mental health research · 2025Article
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31 authors.
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Abstract
Temporal neural synchrony disruption can be linked to a variety of symptoms of major depressive disorder (MDD), including mood rigidity and the inability to break the cycle of negative emotion or attention biases. This might imply that altered dynamic neural synchrony may play a role in the persistence and exacerbation of MDD symptoms. Our study aimed to investigate the changes in whole-brain dynamic patterns of the brain functional connectivity and activity related to depression using the hidden Markov model (HMM) on resting-state functional magnetic resonance imaging (rs-fMRI) data. We compared the patterns of brain functional dynamics in a large sample of 314 patients with MDD (65.9% female; age (mean ± standard deviation): 35.9 ± 13.4) and 498 healthy controls (59.4% female; age: 34.0 ± 12.8). The HMM model was used to explain variations in rs-fMRI functional connectivity and averaged functional activity across the whole-brain by using a set of six unique recurring states. This study compared the proportion of time spent in each state and the average duration of visits to each state to assess stability between different groups. Compared to healthy controls, patients with MDD showed significantly higher proportional time spent and temporal stability in a state characterized by weak functional connectivity within and between all brain networks and relatively strong averaged functional activity of regions located in the somatosensory motor (SMN), salience (SN), and dorsal attention (DAN) networks. Both proportional time spent and temporal stability of this brain state was significantly associated with depression severity. Healthy controls, in contrast to the MDD group, showed proportional time spent and temporal stability in a state with relatively strong functional connectivity within and between all brain networks but weak averaged functional activity across the whole brain. These findings suggest that disrupted brain functional synchrony across time is present in MDD and associated with current depression severity.
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