Evidence map›Paper›PMID 37460457›Full record

ArticleCell death & disease2023

AraC interacts with p75

Vanessa Lopes-Rodrigues, Pia Boxy, Eunice Sim, Dong Ik Park, Michael Habeck, Josep Carbonell, Annika Andersson, Diana Fernández-Suárez, Poul Nissen, Anders Nykjær and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Vanessa Lopes-Rodrigues *Department of Physiology and Life Sciences Institute, National University of Singapore, Singapore, 117597, Singapore.
Pia Boxy *Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Eunice SimDepartment of Physiology and Life Sciences Institute, National University of Singapore, Singapore, 117597, Singapore.
Dong Ik ParkDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Michael HabeckDanish Research Institute of Translational Neuroscience (DANDRITE)-Nordic EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus, Denmark.
Josep CarbonellDepartment of Neuroscience, Karolinska Institute, Stockholm, S-17177, Sweden.ORCID 0000-0003-3568-0520
Annika AnderssonDepartment of Neuroscience, Karolinska Institute, Stockholm, S-17177, Sweden.
Diana Fernández-SuárezDepartment of Neuroscience, Karolinska Institute, Stockholm, S-17177, Sweden.
Poul NissenDanish Research Institute of Translational Neuroscience (DANDRITE)-Nordic EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus, Denmark.
Anders NykjærDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Lilian KisiswaDepartment of Biomedicine, Aarhus University, Aarhus, Denmark. liki@biomed.au.dk.ORCID 0000-0002-1800-0645
Aarhus University · DKKarolinska Institutet · SENational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytosine arabinoside (AraC) is one of the main therapeutic treatments for several types of cancer, including acute myeloid leukaemia. However, after a high-dose AraC chemotherapy regime, patients develop severe neurotoxicity and cell death in the central nervous system leading to cerebellar ataxia, dysarthria, nystagmus, somnolence and drowsiness. AraC induces apoptosis in dividing cells. However, the mechanism by which it leads to neurite degeneration and cell death in mature neurons remains unclear. We hypothesise that the upregulation of the death receptor p75

Indexed as

NeuronsReceptors, Nerve Growth FactorAnimalsApoptosisCell DeathCells, CulturedMiceNeuritesReceptor, Nerve Growth FactorNgfr protein, mouseReceptor, Nerve Growth FactorReceptors, Nerve Growth Factor

Identifiers

PMID37460457
PMCPMC10352303
OpenAlexW4384485925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.