ArticleProceedings of the National Academy of Sciences of the United States of America2023
Bilateral widefield calcium imaging reveals circuit asymmetries and lateralized functional activation of the mouse auditory cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The larvalScience advances · 2026Article
- Self-vocalizations activate the developing auditory cortex via an intracortical pathway.Science advances · 2026Article
- Cortical representation of pitch perception in mice.Communications biology · 2026Article
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- The larvalbioRxiv : the preprint server for biology · 2026Article
- Neuropeptides in control of left-right neural circuits.Trends in neurosciences · 2026Review
- Aging in the Primary Auditory Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- The representation of omitted sounds in the mouse auditory cortex.Nature communications · 2026Article
- Age-related decline in temporal sound processing: insights from envelope steepness map in the mouse auditory cortex.Frontiers in aging neuroscience · 2026Article
- Dysfunctional neural dynamics associated with sensory phenotypes in Fragile X syndrome: insights from mouse models.Journal of neurodevelopmental disorders · 2025Review
- Orthogonal spectral and temporal envelope representation during the onset phase in auditory cortex.iScience · 2025Article
- The universe is asymmetric, the mouse brain too.Molecular psychiatry · 2025Article
- Developmental encoding of natural sounds in the mouse auditory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Receptive-field nonlinearities in primary auditory cortex: a comparative perspective.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Auditory discrimination learning differentially modulates neural representation in auditory cortex subregions and inter-areal connectivity.Cell reports · 2024Article
- Bilateral widefield calcium imaging reveals circuit asymmetries and lateralized functional activation of the mouse auditory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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3 authors.
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Abstract
Coordinated functioning of the two cortical hemispheres is crucial for perception. The human auditory cortex (ACx) shows functional lateralization with the left hemisphere specialized for processing speech, whereas the right analyzes spectral content. In mice, virgin females demonstrate a left-hemisphere response bias to pup vocalizations that strengthens with motherhood. However, how this lateralized function is established is unclear. We developed a widefield imaging microscope to simultaneously image both hemispheres of mice to bilaterally monitor functional responses. We found that global ACx topography is symmetrical and stereotyped. In both male and virgin female mice, the secondary auditory cortex (A2) in the left hemisphere shows larger responses than right to high-frequency tones and adult vocalizations; however, only virgin female mice show a left-hemisphere bias in A2 in response to adult pain calls. These results indicate hemispheric bias with both sex-independent and -dependent aspects. Analyzing cross-hemispheric functional correlations showed that asymmetries exist in the strength of correlations between DM-AAF and A2-AAF, while other ACx areas showed smaller differences. We found that A2 showed lower cross-hemisphere correlation than other cortical areas, consistent with the lateralized functional activation of A2. Cross-hemispheric activity correlations are lower in deaf, otoferlin knockout (OTOF
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