Evidence map›Paper›PMID 37459541›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Proxalutamide reduces SARS-CoV-2 infection and associated inflammatory response.

Yuanyuan Qiao, Jesse W Wotring, Yang Zheng, Charles J Zhang, Yuping Zhang, Xia Jiang, Carla D Pretto, Sanjana Eyunni, Abhijit Parolia, Tongchen He and 12 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 2 institutions in 2 countries.

Yuanyuan QiaoMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-1178-3480
Jesse W WotringDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-7085-7582
Yang ZhengMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-6793-3206
Charles J ZhangDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109.
Yuping ZhangMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Xia JiangMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Carla D PrettoDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Sanjana EyunniMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Abhijit ParoliaMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Tongchen HeMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Caleb ChengMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Xuhong CaoMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Rui WangMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-5356-9685
Fengyun SuMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Stephanie J EllisonMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Yini WangState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.ORCID 0000-0002-1154-6733
Jun QinState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Honghua YanKintor Pharmaceutical Limited, Suzhou Industrial Park, Suzhuo 215123, China.
Qianxiang ZhouKintor Pharmaceutical Limited, Suzhou Industrial Park, Suzhuo 215123, China.
Liandong MaKintor Pharmaceutical Limited, Suzhou Industrial Park, Suzhuo 215123, China.
Jonathan Z SextonDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109.
Arul M ChinnaiyanMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-9282-3415
University of Michigan · USBeijing Proteome Research Center · CN

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Small molecules for expansion of islet beta-cell mass in diabetesR01DK120623 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEWGARD, CHRISTOPHER B, SEXTON, JONATHAN ZACHARY · 2019 to 2021
$2.0M
NIDDK NIH HHS R01 DK120623
6 · The paper itself

Abstract

Early in the COVID-19 pandemic, data suggested that males had a higher risk of developing severe disease and that androgen deprivation therapy might be associated with protection. Combined with the fact that

Indexed as

COVID-19Prostatic NeoplasmsAndrogen AntagonistsAndrogensAnimalsBenzamidesHumansInterferon-gammaMaleMiceNitrilesOxazolesPandemicsPeptidyl-Dipeptidase APhenylthiohydantoinSARS-CoV-2Androgen AntagonistsAndrogensBenzamidesenzalutamideInterferon-gammaNitrilesOxazolesPeptidyl-Dipeptidase APhenylthiohydantoinproxalutamideThiohydantoinsandrogen receptorCOVID-19cytokinesproxalutamideSARS-CoV-2

Identifiers

PMID37459541
PMCPMC10372636
OpenAlexW4384499754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.