Evidence map›Paper›PMID 37459511›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

IL-7R licenses a population of epigenetically poised memory CD8

Goran Micevic, Andrew Daniels, Karine Flem-Karlsen, Koonam Park, Ronan Talty, Meaghan McGeary, Haris Mirza, Holly N Blackburn, Esen Sefik, Julie F Cheung and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. 5-FU chemotherapy induces functional CD7Science China. Life sciences · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Meta-unstable mRNAs in activated CD8Nature communications · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. CD8Cellular & molecular immunology · 2025
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Goran MicevicDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06520.ORCID 0000-0003-0329-1053
Andrew DanielsDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06520.
Karine Flem-KarlsenDepartment of Dermatology, Yale School of Medicine, New Haven, CT 06520.ORCID 0000-0001-8405-3406
Koonam ParkDepartment of Dermatology, Yale School of Medicine, New Haven, CT 06520.
Ronan TaltyDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520.
Meaghan McGearyDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520.
Haris MirzaDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06520.
Holly N BlackburnDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06520.
Esen SefikDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06520.
Julie F CheungDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06520.
Noah I HornickDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06520.ORCID 0000-0002-3503-7693
Lilach AizenbudYale Cancer Center, Yale School of Medicine, New Haven, CT 06520.
Nikhil S JoshiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06520.
Harriet KlugerYale Cancer Center, Yale School of Medicine, New Haven, CT 06520.
Akiko IwasakiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06520.ORCID 0000-0002-7824-9856
Marcus W BosenbergDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06520.
Richard A FlavellDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06520.
Yale University · USYale Cancer Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0M
Yale SPORE in Skin CancerP50CA121974 · NCI · YALE UNIVERSITY · PI RUTH HALABAN · 2006 to 2026
$43.9M
Training in Investigative DermatologyT32AR007016 · NIAMS · YALE UNIVERSITY · PI KEITH A CHOATE, MICHAEL GIRARDI · 1986 to 2026
$7.8M
Cytokine immunotherapies for melanomaU01CA233096 · NCI · YALE UNIVERSITY · PI BOSENBERG, MARCUS W · 2019 to 2019
$3.8M
Renalase inhibition for treatment of unresectable melanomaR01CA216846 · NCI · YALE UNIVERSITY · PI DESIR, GARY V., KLUGER, HARRIET M. · 2017 to 2021
$2.4M
Ferroptosis as a Modulator of Checkpoint Inhibitor ImmunotherapyF30CA254246 · NCI · YALE UNIVERSITY · PI TALTY, RONAN CHRISTOPHER · 2021 to 2023
$95k
Howard Hughes Medical InstituteNCATS NIH HHS UL1 TR001863NCI NIH HHS F30 CA254246NCI NIH HHS P30 CA016359NCI NIH HHS P50 CA121974NCI NIH HHS R01 CA216846NCI NIH HHS U01 CA233096NIAMS NIH HHS T32 AR007016
6 · The paper itself

Abstract

Recurrence of advanced melanoma after therapy is a major risk factor for reduced survival, and treatment options are limited. Antitumor immune memory plays a critical role in preventing melanoma recurrence and memory T cells could be a potent cell-based therapy, but the identity, and functional properties of the required immune cells are incompletely understood. Here, we show that an IL-7R

Indexed as

CD8-Positive T-LymphocytesMelanomaAnimalsAntigensHumansImmunologic MemoryLicensureMemory T CellsMiceSignal TransductionAntigensimmunologyimmunotherapymelanoma

Identifiers

PMID37459511
PMCPMC10372654
OpenAlexW4384498454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.