Evidence map›Paper›PMID 37459448›Full record

ArticleACS synthetic biology2023

A Cell-Free Biosensor for Assessment of Hyperhomocysteinemia.

Fernanda Piorino, Shelbe Johnson, Mark P Styczynski

Open access · hybridAbstract read
In one paragraph

Article in ACS synthetic biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
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  4. Gene circuit-based sensors.Fundamental research · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Fernanda PiorinoSchool of Chemical & Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, Georgia 30332-0100, United States.ORCID 0000-0002-9032-1400
Shelbe JohnsonSchool of Chemical & Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, Georgia 30332-0100, United States.
Mark P StyczynskiSchool of Chemical & Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, Georgia 30332-0100, United States.ORCID 0000-0002-1479-6658
Georgia Institute of Technology · US

Funding

Synthetic biology-based detection of micronutrients with minimal equipmentR01EB022592 · NIBIB · GEORGIA INSTITUTE OF TECHNOLOGY · PI STYCZYNSKI, MARK PHILIP-WALTER · 2017 to 2020
$1.4M
Synthetic biological systems for protein detectionR01EB034301 · NIBIB · GEORGIA INSTITUTE OF TECHNOLOGY · PI Mark Philip-Walter Styczynski · 2023 to 2026
$1.4M
NIBIB NIH HHS R01 EB022592NIBIB NIH HHS R01 EB034301
6 · The paper itself

Abstract

Hyperhomocysteinemia─a condition characterized by elevated levels of homocysteine in the blood─is associated with multiple health conditions including folate deficiency and birth defects, but there are no convenient, low-cost methods to measure homocysteine in plasma. A cell-free biosensor that harnesses the native homocysteine sensing machinery of

Indexed as

Folic Acid DeficiencyHyperhomocysteinemiaCross-Sectional StudiesFolic AcidHumansMultimorbidityVitamin B 12Folic AcidVitamin B 12cell-free biosensordiagnosticsfolate deficiencyhomocysteinehyperhomocysteinemiamonitoring

Identifiers

PMID37459448
PMCPMC10443029
OpenAlexW4384498562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.