Evidence map›Paper›PMID 37459398›Full record

ArticleBiochemistry2023

Probing Protein Dynamics in Neuronal Nitric Oxide Synthase by Quantitative Cross-Linking Mass Spectrometry.

Ting Jiang, Guanghua Wan, Haikun Zhang, Yadav Prasad Gyawali, Eric S Underbakke, Changjian Feng

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Detection of a clamp-shaped conformation of a neuronal nitric oxide synthase construct by pulsed EPR.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Article
  3. Analyzing the FMN-heme interdomain docking interactions in neuronal and inducible NOS isoforms by pulsed EPR experiments and conformational distribution modeling.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024
    Article
  4. Article
  5. Article
  6. Roadmap to advance therapeutics forTherapeutic advances in rare disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ting JiangCollege of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, United States.
Guanghua WanCollege of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, United States.
Haikun ZhangCollege of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, United States.
Yadav Prasad GyawaliCollege of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, United States.
Eric S UnderbakkeRoy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, Iowa 50011, United States.ORCID 0000-0003-4269-7339
Changjian FengCollege of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, United States.ORCID 0000-0003-4542-6497
University of New Mexico · USIowa State University · US

Funding

University of New Mexico Center for Metals in Biology and Medicine - equipment supplementP20GM130422 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Matthew J Campen · 2020 to 2026
$20.4M
Pilot Project CoreP30ES032755 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BLOSSOM, SARAH J · 2022 to 2025
$5.2M
Defining the conformational control of nitric oxide synthases by a multipronged approachR01GM133973 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI FENG, CHANGJIAN · 2020 to 2023
$1.5M
NIEHS NIH HHS P30 ES032755NIGMS NIH HHS P20 GM130422NIGMS NIH HHS R01 GM133973
6 · The paper itself

Abstract

Nitric oxide synthase (NOS) is responsible for the biosynthesis of nitric oxide (NO), an important signaling molecule controlling diverse physiological processes such as neurotransmission and vasodilation. Neuronal NOS (nNOS) is a calmodulin (CaM)-controlled enzyme. In the absence of CaM, several intrinsic control elements, along with NADP

Indexed as

CalmodulinMass SpectrometryNitric Oxide Synthase Type IAnimalsCross-Linking ReagentsHumansNADPNitric OxideProtein ConformationCalmodulinCross-Linking ReagentsNADPNitric OxideNitric Oxide Synthase Type I

Identifiers

PMID37459398
PMCPMC10529231
OpenAlexW4384499158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.