Evidence map›Paper›PMID 37459272›Full record

ArticleMolecular pharmaceutics2023

Cancer Cell Membrane Wrapped Nanoparticles for the Delivery of a Bcl-2 Inhibitor to Triple-Negative Breast Cancer.

Mackenzie A Scully, Dana E Wilkins, Megan N Dang, Elise C Hoover, Sara B Aboeleneen, Emily S Day

Open access · greenAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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  8. Membrane-modified lipid nanoparticles for RNA delivery.Molecular therapy. Methods & clinical development · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mackenzie A ScullyDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware 19713, United States.
Dana E WilkinsDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware 19713, United States.
Megan N DangDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware 19713, United States.ORCID 0000-0002-4222-3355
Elise C HooverDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware 19713, United States.ORCID 0000-0003-4723-7446
Sara B AboeleneenDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware 19713, United States.ORCID 0000-0003-1068-4349
Emily S DayDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware 19713, United States.ORCID 0000-0002-8707-826X
University of Delaware · US

Funding

Understanding synovial macrophage inflamm-aging within osteoarthritisP20GM139760 · NIGMS · UNIVERSITY OF DELAWARE · PI DAWN M ELLIOTT · 2021 to 2026
$19.1M
Multifunctional siRNA/antibody nanocarriers to treat metastatic triple-negative breast cancerR01CA211925 · NCI · UNIVERSITY OF DELAWARE · PI DAY, EMILY S · 2019 to 2023
$1.7M
NCI NIH HHS R01 CA211925NIGMS NIH HHS P20 GM139760
6 · The paper itself

Abstract

Overexpression of the antiapoptotic protein B-cell lymphoma 2 (Bcl-2) is correlated with poor survival outcomes in triple-negative breast cancer (TNBC), making Bcl-2 inhibition a promising strategy to treat this aggressive disease. Unfortunately, Bcl-2 inhibitors developed to date have limited clinical success against solid tumors, owing to poor bioavailability, insufficient tumor delivery, and off-target toxicity. To circumvent these problems, we loaded the Bcl-2 inhibitor ABT-737 in poly(lactic-

Indexed as

Antineoplastic AgentsNanoparticlesTriple Negative Breast NeoplasmsAnimalsBiphenyl CompoundsCell Line, TumorCell MembraneHumansMiceNitrophenolsPiperazinesPolyestersPolyethylene GlycolsSulfonamidesABT-737Antineoplastic AgentsBiphenyl CompoundsNitrophenolsPiperazinesPolyesterspoly(ethyleneglycol-lactide)polyethylene glycol-poly(lactide-co-glycolide)Polyethylene GlycolsSulfonamidesABT-737biomimicrymembrane-wrappedmetastasisnanomedicineoncologytargeted chemotherapy

Identifiers

PMID37459272
PMCPMC10628893
OpenAlexW4384521864

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.