Evidence map›Paper›PMID 37459233›Full record

ArticleCell reports2023

Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells.

Fenghua Qian, Shaneice K Nettleford, Jiayan Zhou, Brooke E Arner, Molly A Hall, Arati Sharma, Charyguly Annageldiyev, Randy M Rossi, Diwakar B Tukaramrao, Deborpita Sarkar and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Fenghua QianDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Shaneice K NettlefordDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Jiayan ZhouDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Brooke E ArnerDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Molly A HallDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Arati SharmaDepartment of Medicine, Division of Hematology and Oncology, Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Charyguly AnnageldiyevDepartment of Medicine, Division of Hematology and Oncology, Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Randy M RossiTransgenic Core Facility, Huck Institute of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Diwakar B TukaramraoDepartment of Medicine, Division of Hematology and Oncology, Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Deborpita SarkarDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Shailaja HegdeHoxworth Blood Center, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Ujjawal H GandhiDepartment of Hematology and Oncology, University of North Carolina Health, Cary, NC 27518, USA.
Emily R FinchDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Laura GoodfieldImmunooncology Division, Bicycle Therapeutics, Boston, MA 02140, USA.
Michael D QuickelDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
David F ClaxtonDepartment of Medicine, Division of Hematology and Oncology, Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Robert F PaulsonDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address: rfp5@psu.edu.
K Sandeep PrabhuDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address: ksp4@psu.edu.
Pennsylvania State University · USCincinnati Children's Hospital Medical Center · USSt. Jude Children's Research Hospital · US

Funding

Tissue Repository and Animal Models CoreP01CA171983 · NCI · UNIVERSITY OF VIRGINIA · PI CHALFANT, CHARLES E. · 2013 to 2024
$19.9M
Cellular Selenium Status and PGJ2 Metabolism (PA-17-078 supplement 2017)R01DK077152 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PRABHU, KUMBLE SANDEEP · 2008 to 2018
$2.5M
NCI NIH HHS P01 CA171983NIDDK NIH HHS R01 DK077152
6 · The paper itself

Abstract

Relapse of acute myeloid leukemia (AML) remains a significant concern due to persistent leukemia-initiating stem cells (LICs) that are typically not targeted by most existing therapies. Using a murine AML model, human AML cell lines, and patient samples, we show that AML LICs are sensitive to endogenous and exogenous cyclopentenone prostaglandin-J (CyPG), Δ

Indexed as

Leukemia, Myeloid, AcuteSeleniumAnimalsCell LineHumansMicePhosphatidylinositol 3-KinasesSignal TransductionPhosphatidylinositol 3-KinasesSeleniumCP: CancerCRTH2KRASleukemiaMAP kinasep53PPARprostaglandinsRTKselenium

Identifiers

PMID37459233
PMCPMC10428076
OpenAlexW4384626499

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.