Evidence map›Paper›PMID 37459116›Full record

ArticleJournal of medicinal chemistry2023

Evaluating Alkaline Phosphatase-Instructed Self-Assembly of d-Peptides for Selectively Inhibiting Ovarian Cancer Cells.

Meihui Yi, Zhaoqianqi Feng, Hongjian He, Daniela Dinulescu, Bing Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Meihui YiDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02453, United States.ORCID 0000-0002-1912-1043
Zhaoqianqi FengDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02453, United States.ORCID 0000-0002-1262-385X
Hongjian HeDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02453, United States.
Daniela DinulescuDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Bing XuDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02453, United States.ORCID 0000-0002-4639-387X

Funding

Subcellular Enzyme-instructed self-assembly for molecular anticancer nanomedicinesR01CA142746 · NCI · BRANDEIS UNIVERSITY · PI Bing Xu · 2010 to 2026
$6.4M
Exploring enzyme-instructed self-assembly (EISA) for targeting osteoblastic metastasis of prostate cancerR21CA252364 · NCI · BRANDEIS UNIVERSITY · PI HSIEH, JER-TSONG, XU, BING · 2020 to 2020
$430k
NCI NIH HHS R01 CA142746NCI NIH HHS R21 CA252364
6 · The paper itself

Abstract

Cancer is a major public health concern requiring novel treatment approaches. Enzyme-instructed self-assembly (EISA) provides a unique approach for selectively inhibiting cancer cells. However, the structure and activity correlation of EISA remains to be explored. This study investigates new EISA substrates of alkaline phosphatase (ALP) to hinder ovarian cancer cells. Analogues

Indexed as

Alkaline PhosphataseOvarian NeoplasmsCell LineCell Line, TumorFemaleHumansPeptidesAlkaline PhosphatasePeptides

Identifiers

PMID37459116
PMCPMC10614160

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.