Evidence map›Paper›PMID 37459107›Full record

Observational studyJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023

Exploring sex differences for acute ischemic stroke clinical, imaging and thrombus characteristics in the INTERRSeCT study.

Alexander D Rebchuk, Michael D Hill, Mayank Goyal, Andrew Demchuk, Shelagh B Coutts, Negar Asdaghi, Dar Dowlatshahi, Jessalyn K Holodinsky, Enrico Fainardi, Jai Shankar and 6 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Genetic determinants of insufficiency of the collateral circulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  2. Sex and gender-related differences in neurological diseases: current challenges and recommendations for clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  3. Article
  4. Endothelial lincRNA-p21 alleviates cerebral ischemia/reperfusion injury by maintaining blood-brain barrier integrity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 4 countries.

Alexander D RebchukDivision of Neurosurgery, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-5553-346X
Michael D HillDepartment of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID 0000-0002-6269-1543
Mayank GoyalDepartment of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Andrew DemchukDepartment of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Shelagh B CouttsDepartment of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Negar AsdaghiDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Dar DowlatshahiSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Jessalyn K HolodinskyDepartment of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Enrico FainardiDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Jai ShankarDepartment of Radiology, University of Manitoba, Winnipeg, MB, Canada.
Mohamed NajmDepartment of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Marta RubieraNeurology Department, Hospital Vall d'Hebron, Barcelona, Spain.
Alexander V KhawDepartment of Clinical Neurosciences, University of Western Ontario, London, ON, Canada.
Wu QiuDepartment of Radiology, University of Calgary, Calgary, AB, Canada.ORCID 0000-0001-7827-8270
Bijoy K MenonDepartment of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Thalia S FieldDivision of Neurology, University of British Columbia, Vancouver, BC, Canada.
University of Calgary · CAUniversity of British Columbia · CAUniversity of Florence · ITUniversity of Manitoba · CAUniversity of Miami · USUniversity of Ottawa · CAVall d'Hebron Hospital Universitari · ESWestern University · CA

Funding

CIHR
6 · The paper itself

Abstract

Women, especially following menopause, are known to have worse outcomes following acute ischemic stroke. One primary postulated biological mechanism for worse outcomes in older women is a reduction in the vasculoprotective effects of estrogen. Using the INTERRseCT cohort, a multicentre international observational cohort studying recanalization in acute ischemic stroke, we explored the effects of sex, and modifying effects of age, on neuroradiological predictors of recanalization including robustness of leptomeningeal collaterals, thrombus burden and thrombus permeability. Ordinal regression analyses were used to examine the relationship between sex and each of the neuroradiological markers. Further, we explored both multiplicative and additive interactions between age and sex. All patients (n = 575) from INTERRseCT were included. Mean age was 70.2 years (SD: 13.1) and 48.5% were women. In the unadjusted model, female sex was associated with better collaterals (OR 1.37, 95% CIs: 1.01-1.85), however this relationship was not significant after adjusting for age and relevant comorbidities. There were no significant interactions between age and sex. In a large prospective international cohort, we found no association between sex and radiological predictors of recanalization including leptomeningeal collaterals, thrombus permeability and thrombus burden.

Indexed as

Brain IschemiaIschemic StrokeStrokeThrombosisAgedAged, 80 and overFemaleHumansMaleProspective StudiesRetrospective StudiesSex CharacteristicsTreatment OutcomecollateralsmenopauserecanalizationStrokethrombus

Identifiers

PMID37459107
PMCPMC10581233
OpenAlexW4384522484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.