Evidence map›Paper›PMID 37458986›Full record

ReviewMolecular neurobiology2023

Syntaphilin Inactivation Can Enhance Axonal Mitochondrial Transport to Improve Spinal Cord Injury.

Qicheng Lu, Yong Zhang, Benson O A Botchway, Min Huang, Xuehong Liu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Qicheng Lu *Department of Histology and Embryology, Medical College, Shaoxing University, Shaoxing, 312000, Zhejiang, China.
Yong Zhang *Department of Histology and Embryology, Medical College, Shaoxing University, Shaoxing, 312000, Zhejiang, China.
Benson O A Botchway *Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China.
Min HuangDepartment of Histology and Embryology, Medical College, Shaoxing University, Shaoxing, 312000, Zhejiang, China.
Xuehong LiuDepartment of Histology and Embryology, Medical College, Shaoxing University, Shaoxing, 312000, Zhejiang, China. liuxueh6588@126.com.ORCID http://orcid.org/0000-0003-4325-6762
Shaoxing University · CNBupa Cromwell Hospital · GB

Funding

Natural Science Foundation of Zhejiang Province LY19H170001
6 · The paper itself

Abstract

Mitochondria are important organelle of eukaryotic cells. They consists of a large number of different proteins that provide most of the ATP and supply power for the growth, function, and regeneration of neurons. Therefore, smitochondrial transport ensures that adequate ATP is supplied for metabolic activities. Spinal cord injury (SCI), a detrimental condition, has high morbidity and mortality rates. Currently, the available treatments only provide symptomatic relief for long-term disabilities. Studies have implicated mitochondrial transport as a critical factor in axonal regeneration. Hence, enhancing mitochondrial transports could be beneficial for ameliorating SCI. Syntaphilin (Snph) is a mitochondrial docking protein that acts as a "static anchor," and its inhibition enhances mitochondrial transports. Therefore, Snph as a key mediator of mitochondrial transports, may contribute to improving axonal regeneration following SCI. Herein, we examine Snph's biological effects and its relation to mitochondrial pathway. Then, we elaborate on mitochondrial transports after SCI, the possible role of Snph in SCI, and some possible therapeutic approaches by Snph.

Indexed as

AxonsSpinal Cord InjuriesAdenosine TriphosphateAxonal TransportHumansMicrotubule-Associated ProteinsMitochondriaNerve RegenerationSpinal CordAdenosine TriphosphateMicrotubule-Associated ProteinsAkt-PAK5 signalingAxon regenerationMitochondrial transportP21 activated kinase 5 (PAK5)Spinal cord injury (SCI)Syntaphilin (Snph)

Identifiers

PMID37458986
OpenAlexW4384525137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.