Evidence map›Paper›PMID 37458930›Full record

ArticleJournal of endocrinological investigation2024

Association of serum lipids and abnormal lipid score with cancer risk: a population-based prospective study.

Y Xie, Y Jiang, Y Wu, X Su, D Zhu, P Gao, H Yuan, Y Xiang, J Wang, Q Zhao and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Squalene Epoxidase: Its Regulations and Links with Cancers.International journal of molecular sciences · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Exosomal microRNAs in lung cancer: a narrative review.Translational cancer research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Y XieDepartment of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Y JiangSongjiang District Center for Disease Control and Prevention, Shanghai, China.
Y WuSongjiang District Center for Disease Control and Prevention, Shanghai, China.
X SuSongjiang District Center for Disease Control and Prevention, Shanghai, China.
D ZhuDepartment of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
P GaoState Key Laboratory of Genetic Engineering, Human Phenome Institute, and School of Life Sciences, Fudan University, Shanghai, China.
H YuanState Key Laboratory of Genetic Engineering, Human Phenome Institute, and School of Life Sciences, Fudan University, Shanghai, China.
Y XiangDepartment of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
J WangDepartment of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Q ZhaoDepartment of Social Medicine, School of Public Health, Fudan University, Shanghai, China.
K XuDepartment of Biostatistics, School of Public Health, Fudan University, Shanghai, China.
T ZhangDepartment of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Q ManDepartment of Clinical Laboratory, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, China.
X ChenFudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China.
G ZhaoDepartment of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Y JiangState Key Laboratory of Genetic Engineering, Human Phenome Institute, and School of Life Sciences, Fudan University, Shanghai, China.
C SuoDepartment of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China. suochen@fudan.edu.cn.ORCID http://orcid.org/0000-0002-5274-4584
Fudan University · CNSongjiang District Central Hospital · CNTongji University · CN

Funding

Discipline Promotion Program of Shanghai Fourth People's Hospital SY-XKZT-2020-1002National Key Research and Development Program of China 2017YFC0907000National Key Research and Development Program of China 2019YFC1315804National Natural Science Foundation of China 82073637National Natural Science Foundation of China 82122060Science and Technology Commission of Shanghai Municipality, China 20ZR1405600Three-Year Action Plan for Strengthening Public Health System in Shanghai GWV-10.2-YQ32
6 · The paper itself

Abstract

backgroundSerum lipid levels are associated with cancer risk. However, there still have uncertainties about the single and combined effects of low lipid levels on cancer risk.

methodsA prospective cohort study of 33,773 adults in Shanghai between 2016 and 2017 was conducted. Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels were measured. Cox proportional hazard models were used to assess the association of single and combined lipids with overall, lung, colon, rectal, thyroid gland, stomach, and female breast cancers. The effect of the combination of abnormal lipid score and lifestyle on cancer was also estimated.

resultsA total of 926 incident cancer cases were identified. In the RCS analysis, hazard ratios (HRs) of overall cancer for individuals with TC < 5.18 mmol/L or with LDL-C < 3.40 mmol/L were higher. Low TC was associated with higher colorectal cancer risk (HR [95% CI] = 1.76 [1.09-2.84]) and low HDL-C increased thyroid cancer risk by 90%. Abnormal lipid score was linearly and positively associated with cancer risk, and smokers with high abnormal lipid scores had a higher cancer risk, compared to non-smokers with low abnormal lipid scores (P < 0.05).

conclusionsLow TC levels were associated with an increased risk of overall and colorectal cancer. More attention should be paid to participants with high abnormal lipid scores and unhealthy lifestyles who may have a higher risk of developing cancer. Determining the specific and comprehensive lipid combinations that affect tumorigenesis remains a valuable challenge.

Indexed as

Colorectal NeoplasmsLipidsAdultChinaCholesterol, HDLCholesterol, LDLFemaleHumansProspective StudiesRisk FactorsTriglyceridesCholesterol, HDLCholesterol, LDLLipidsTriglyceridesAbnormal lipid scoreColorectal cancerLow cholesterolThyroid cancer

Identifiers

PMID37458930
OpenAlexW4384523102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.