Evidence map›Paper›PMID 37458712›Full record

ArticleEnvironmental health perspectives2023

Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Subchronically Exposed to Ambient Particulate Matter.

Rui Zhang, Shen Chen, Ziwei Wang, Lizhu Ye, Yue Jiang, Miao Li, Xinhang Jiang, Hui Peng, Zhanyu Guo, Liping Chen and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Integrative multi-omic analysis identifiedCancer biology & medicine · 2026
    Article
  3. Real-ambient PMParticle and fibre toxicology · 2025
    Article
  4. Disruption of Gut Microbiota-Mediated De Novo NADAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Article
  6. The role of nicotinamide adenine dinucleotide salvage enzymes in cardioprotection.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2024
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Rui ZhangDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Shen ChenDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Ziwei WangDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Lizhu YeDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Yue JiangDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Miao LiDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Xinhang JiangDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Hui PengDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Zhanyu GuoDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Liping ChenDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Rong ZhangDepartment of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang, China.
Yujie NiuDepartment of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang, China.
Michael AschnerDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA.
Daochuan LiDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Wen ChenDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0001-5435-1664
Sun Yat-sen University · CNHebei Medical University · CNAlbert Einstein College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic lung injury and dysregulated cellular homeostasis in response to particulate matter (PM) exposure are closely associated with adverse health effects. However, an effective intervention for preventing the adverse health effects has not been developed.

objectivesThis study aimed to evaluate the protective effects of nicotinamide mononucleotide (NMN) supplementation on lung injury and elucidate the mechanism by which NMN improved immune function following subchronic PM exposure.

methodsSix-week-old male C57BL/6J mice were placed in a real-ambient PM exposure system or filtered air-equipped chambers (control) for 16 wk with or without NMN supplementation in drinking water (regarded as

resultsThe NMN-treated mice exhibited higher DISCUSSION: Our novel findings suggest that NMN supplementation mitigated PM-induced lung injury by regulating immune functions and improving lipid metabolism in male mice, providing a putative intervention method for prevention of human health effects associated with PM exposure. https://doi.org/10.1289/EHP12259.

Indexed as

Lung InjuryPneumoniaAnimalsDietary SupplementsHumansMaleMiceMice, Inbred C57BLNicotinamide MononucleotideParticulate MatterNicotinamide MononucleotideParticulate Matter

Identifiers

PMID37458712
PMCPMC10351503
OpenAlexW4384564270

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.