Evidence map›Paper›PMID 37458393›Full record

ArticleJournal of materials chemistry. B2023

Development of a bioactive tunable hyaluronic-protein bioconjugate hydrogel for tissue regenerative applications.

Mary Kasper, Madison Cydis, Abdullah Afridi, Bassam M Smadi, Yuan Li, Alban Charlier, Brooke E Barnes, Julia Hohn, Michael J Cline, Wayne Carver and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials chemistry. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Mary KasperJ Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, USA. schmidt@bme.ufl.edu.
Madison CydisJ Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, USA. schmidt@bme.ufl.edu.
Abdullah AfridiDepartment of Chemistry, University of Florida, Gainesville, USA.
Bassam M SmadiJ Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, USA. schmidt@bme.ufl.edu.ORCID 0009-0007-3263-0380
Yuan LiJ Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, USA. schmidt@bme.ufl.edu.
Alban CharlierDepartment of Chemistry, University of Florida, Gainesville, USA.
Brooke E BarnesDepartment of Chemistry, University of Florida, Gainesville, USA.
Julia HohnDepartment of Cell Biology and Anatomy, University of South Carolina, Columbia, USA.ORCID 0000-0002-3664-7653
Michael J ClineDepartment of Chemical Engineering, University of Florida, Gainesville, USA.ORCID 0009-0006-0381-5872
Wayne CarverDepartment of Cell Biology and Anatomy, University of South Carolina, Columbia, USA.
Michael MatthewsDepartment of Chemical Engineering, University of South Carolina, Columbia, USA.
Daniel SavinDepartment of Chemistry, University of Florida, Gainesville, USA.
Carlos M Rinaldi-RamosJ Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, USA. schmidt@bme.ufl.edu.ORCID 0000-0001-8886-5612
Christine E SchmidtJ Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, USA. schmidt@bme.ufl.edu.
University of Florida · USUniversity of South Carolina · US

Funding

The Tissue-Engineered Electronic Nerve Interface (TEENI)R01NS111518 · NINDS · UNIVERSITY OF FLORIDA · PI JUDY, JACK W · 2019 to 2022
$2.4M
NINDS NIH HHS R01 NS111518
6 · The paper itself

Abstract

Every year, there are approximately 500 000 peripheral nerve injury (PNI) procedures due to trauma in the US alone. Autologous and acellular nerve grafts are among current clinical repair options; however, they are limited largely by the high costs associated with donor nerve tissue harvesting and implant processing, respectively. Therefore, there is a clinical need for an off-the-shelf nerve graft that can recapitulate the native microenvironment of the nerve. In our previous work, we created a hydrogel scaffold that incorporates mechanical and biological cues that mimic the peripheral nerve microenvironment using chemically modified hyaluronic acid (HA). However, with our previous work, the degradation profile and cell adhesivity was not ideal for tissue regeneration, in particular, peripheral nerve regeneration. To improve our previous hydrogel, HA was conjugated with fibrinogen using Michael-addition to assist in cell adhesion and hydrogel degradability. The addition of the fibrinogen linker was found to contribute to faster scaffold degradation

Indexed as

Tissue EngineeringAnimalsCell LineFibrinogenHyaluronic AcidHydrogelsRatsFibrinogenHyaluronic AcidHydrogels

Identifiers

PMID37458393
PMCPMC10528782
OpenAlexW4384571710

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.