Evidence map›Paper›PMID 37458373›Full record

ReviewJournal of medicinal chemistry2023

Targeting EP2 Receptor for Drug Discovery: Strengths, Weaknesses, Opportunities, and Threats (SWOT) Analysis.

Thota Ganesh

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Neuroinflammation and Disease: Pathways and Opportunities.Annual review of pharmacology and toxicology · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Spatial mapping of the AA-PGEActa neuropathologica · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Engineering Nanoscale Drug Delivery Systems for Pain.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Thota GaneshDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.ORCID 0000-0002-6163-5590
Emory University · US

Funding

Development of EP2 Receptor Antagonist to Treat Alzheimer's DiseaseU01AG088113 · NIA · EMORY UNIVERSITY · PI Thota Ganesh, Tage Honore · 2024 to 2026
$5.0M
Development of EP2 receptor antagonists for suppression of Alzheimer's neuropathologyU01AG052460 · NIA · EMORY UNIVERSITY · PI GANESH, THOTA · 2016 to 2020
$3.9M
Optimization of EP2 Antagonists for Post-Seizure Cognitive DeficitsUH3NS127386 · NINDS · EMORY UNIVERSITY · PI GANESH, THOTA · 2023 to 2024
$1.3M
EP2 antagonists as novel anti-epileptogenic agentsR21NS101167 · NINDS · EMORY UNIVERSITY · PI GANESH, THOTA · 2018 to 2019
$747k
Optimization of EP2 Antagonists for Post-Seizure Cognitive DeficitsUG3NS127386 · NINDS · EMORY UNIVERSITY · PI DINGLEDINE, RAYMOND J, GANESH, THOTA · 2022 to 2022
$678k
EP2 Antagonist Development for Post-seizure Cognitive DeficitsUG3NS113879 · NINDS · EMORY UNIVERSITY · PI DINGLEDINE, RAYMOND J, GANESH, THOTA · 2020 to 2020
$475k
EP2 antagonists as novel anti-epileptogenic agentsR33NS101167 · NINDS · EMORY UNIVERSITY · PI GANESH, THOTA · 2020 to 2020
$389k
NIA NIH HHS U01 AG052460NIA NIH HHS U01 AG088113NINDS NIH HHS R21 NS101167NINDS NIH HHS R33 NS101167NINDS NIH HHS UG3 NS113879NINDS NIH HHS UG3 NS127386NINDS NIH HHS UH3 NS127386
6 · The paper itself

Abstract

Cyclooxygenase-1 and -2 (COX1 and COX2) derived endogenous ligand prostaglandin-E

Indexed as

DinoprostoneReceptors, Prostaglandin EAnimalsCyclooxygenase 2Drug DiscoveryMiceReceptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 SubtypeCyclooxygenase 2DinoprostoneReceptors, Prostaglandin EReceptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 Subtype

Identifiers

PMID37458373
PMCPMC10388357
OpenAlexW4384559600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.