Evidence map›Paper›PMID 37458356›Full record

ArticleeLife2023

p38γ and p38δ modulate innate immune response by regulating MEF2D activation.

Alejandra Escós, Ester Diaz-Mora, Michael Pattison, Pilar Fajardo, Diego González-Romero, Ana Risco, José Martín-Gómez, Éric Bonneil, Nahum Sonenberg, Seyed Mehdi Jafarnejad and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. p38γ and p38δ MAP kinases in inflammation.Biochemical Society transactions · 2026
    Review
  2. Review
  3. Article
  4. p38γ and p38δ support CD4Frontiers in immunology · 2026
    Article
  5. Article
  6. VTA-ACC dopaminergic circuit mediates trait anxiety-related observational learning of social avoidance in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 5 countries.

Alejandra Escós *Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC (CNB-CSIC), Campus-UAM, Madrid, Spain.ORCID 0000-0002-2990-7920
Ester Diaz-Mora *Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC (CNB-CSIC), Campus-UAM, Madrid, Spain.ORCID 0000-0002-4233-0943
Michael PattisonThe Francis Crick Institute, London, United Kingdom.
Pilar FajardoDepartment of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC (CNB-CSIC), Campus-UAM, Madrid, Spain.ORCID 0000-0001-8398-7354
Diego González-RomeroDepartment of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC (CNB-CSIC), Campus-UAM, Madrid, Spain.ORCID 0000-0002-0564-3326
Ana RiscoDepartment of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC (CNB-CSIC), Campus-UAM, Madrid, Spain.
José Martín-GómezDepartment of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC (CNB-CSIC), Campus-UAM, Madrid, Spain.
Éric BonneilInstitute for Research in Immunology and Cancer, Université de Montréal, Montreal, Canada.
Nahum SonenbergGoodman Cancer Research Center, McGill University, Montreal, Canada.ORCID 0000-0002-4707-8759
Seyed Mehdi JafarnejadPatrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0002-5129-7081
Juan José Sanz-EzquerroDepartment of Molecular and Cellular Biology, CNB-CSIC, Madrid, Spain.ORCID 0000-0002-9084-6354
Steven C LeyThe Francis Crick Institute, London, United Kingdom.ORCID 0000-0001-5911-9223
Ana CuendaDepartment of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC (CNB-CSIC), Campus-UAM, Madrid, Spain.ORCID 0000-0002-9013-5077
The Francis Crick Institute · GBCentro Nacional de Biotecnología · ESGoodman (Japan) · JPInstitute for Research in Immunology and Cancer · CAQueen's University Belfast · GB

Funding

Cancer Research UK FC001103Medical Research Council FC001103Wellcome Trust FC001103
6 · The paper itself

Abstract

Evidence implicating p38γ and p38δ (p38γ/p38δ) in inflammation are mainly based on experiments using

Indexed as

LipopolysaccharidesMitogen-Activated Protein Kinase 13AnimalsImmunity, InnateInflammationMiceMitogen-Activated Protein Kinase 12ProteomicsLipopolysaccharidesMitogen-Activated Protein Kinase 12Mitogen-Activated Protein Kinase 13biochemistrychemical biologyimmunologyinflammationMAPKMEF2Dmousep38γp38δphosphorylation

Identifiers

PMID37458356
PMCPMC10400073
OpenAlexW4384523771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.