ArticleCNS neuroscience & therapeutics2023
Epstein-Barr virus: To be a trigger of autoimmune glial fibrillary acidic protein astrocytopathy?
Article in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- EBV-associated autoimmune glial fibrillary acidic protein astrocytopathy with lumbosacral leptomeningeal enhancement: a case report and literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Characteristics and prognostic factors of cognitive impairment in autoimmune glial fibrillary acidic protein astrocytopathy.Journal of neurology · 2026Article
- A case of novel meningoencephalomyelitis associated with vimentin IgG autoantibodies.BMC neurology · 2026Article
- Autoimmune glial fibrillary acidic protein astrocytopathy with full-length spinal cord lesions: a case report and literature review.BMC neurology · 2026Review
- Clinical characteristics of autoimmune GFAP astrocytopathy with concomitant Epstein-Barr virus positivity: a case series of 12 patients and literature review.Journal of neurology · 2026Review
- Myelin oligodendrocyte glycoprotein antibody-associated disease presenting as encephalitis and concurrent Epstein-Barr virus detection: a case series.Frontiers in immunology · 2026Article
- Clinical features associated with cerebrospinal fluid Epstein-Barr virus positivity in autoimmune GFAP astrocytopathy: a multicenter retrospective cohort study.Frontiers in neurology · 2026Observational
- A case report of autoimmune glial fibrillary acidic protein astrocytopathy combined with Epstein-Barr virus infection.BMC neurology · 2025Article
- Novel Perspectives Focused on the Relationship Between Herpesvirus Encephalitis and Anti-GFAP-Antibody-Positive Astrocytopathy.Molecular neurobiology · 2025Review
- A Comparative Study of 141 Glial Fibrillary Acidic Protein Immunoglobulin G Positive Cases.European journal of neurology · 2025Article
- Novel Meningoencephalomyelitis Associated With Vimentin IgG Autoantibodies.JAMA neurology · 2025Article
- Myelitis associated with glial fibrillary acidic protein IgG: characterization and comparison with aquaporin-4 IgG and myelin oligodendrocyte glycoprotein IgG myelitis.BMC neurology · 2025Article
- Therapeutic efficacy of telitacicept in a patient with GFAP autoimmune astrocytopathy: a case report.Frontiers in immunology · 2025Article
- Successful sequential treatment with ofatumumab followed by efgartigimod for refractory autoimmune encephalitis with dual anti-NMDAR and anti-GFAP antibody positivity: first case report.Frontiers in immunology · 2025Article
- Predicting ICU Admission in Patients with Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy.ImmunoTargets and therapy · 2025Article
- Clinical characteristics and MRI features of autoimmune glial fibrillary acidic protein astrocytopathy: a case series of 34 patients.Frontiers in neurology · 2024Article
- Epstein-Barr virus: To be a trigger of autoimmune glial fibrillary acidic protein astrocytopathy?CNS neuroscience & therapeutics · 2023Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAutoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a novel autoimmune disease of central nervous system (CNS). It is unclear whether Epstein-Barr virus (EBV) is related to autoimmune GFAP astrocytopathy.
objectiveTo describe the clinical, laboratory, and imaging characteristics of patients with autoimmune GFAP astrocytopathy.
methodsThe clinical, laboratory, and imaging findings of patients are presented. The levels of GFAP in CSF were detected by ELISA. T and B cell subsets in CSF were detected by flow cytometry. GFAP-IgG in serum and cerebrospinal fluid (CSF) were tested by cell-based assay (CBA) and tissue-based assay (TBA).
resultsAll three patients had fever, cognitive dysfunction, limb weakness, and positive GFAP-IgG with EBV infection in CSF. Enteric glia cells may involve in this disease. Typical imaging findings include the gadolinium enhancement of linear perivascular radial perpendicular to the ventricle, meningeal enhancement (especially in midbrain interpeduncal fossa), longitudinally extensive lesions involving spindle cords, and more T2/Flair-hyperintense lesions in the periventricular white matter at late stage. The patients had poor response to antiviral treatment and strong response to steroid pulse therapy.
conclusionEBV could induce CNS autoimmune response in autoimmune GFAP astrocytopathy. The detection of GFAP-IgG and EBV may facilitate the early diagnosis in these patients.
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