Evidence map›Paper›PMID 37457958›Full record

ArticleFrontiers in cellular and infection microbiology2023

Optimal treatment of ceftazidime-avibactam and aztreonam-avibactam against bloodstream infections or lower respiratory tract infections caused by extensively drug-resistant or pan drug-resistant (XDR/PDR)

Yixin Kang, Lu Xie, Jiyong Yang, Junchang Cui

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. In vitro activity of aztreonam-avibactam against carbapenem-resistant Pseudomonas aeruginosa from Southern Brazil.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  3. Review
  4. Observational
  5. Article
  6. Article
  7. Pharmacodynamic target attainment of the synergism of ceftazidime-avibactam in combination with amikacin against OXA-producing extensively drug-resistant or pan drug-resistant (XDR/PDR) Pseudomonas aeruginosa.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  8. Difficult-to-TreatAntibiotics (Basel, Switzerland) · 2025
    Review
  9. Infection and drug resistance · 2025
    Article
  10. The Role ofInfection and drug resistance · 2025
    Article
  11. Tracing the evolutionary trajectory of the IncP-2 plasmid co-harboringFrontiers in cellular and infection microbiology · 2025
    Article
  12. Metabolomics unveil key pathways underlying the synergistic activities of aztreonam and avibactam against multidrug-resistant Escherichia coli.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Yixin KangDepartment of Respiratory Diseases, The first Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China.
Lu XieResearch Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province, Guangzhou, China.
Jiyong YangDepartment of Laboratory, The First Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China.
Junchang CuiCollege of Pulmonary & Critical Care Medicine, 8th Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China.
Chinese People's Liberation Army · CNKey Laboratory of Guangdong Province · CNPeople's Liberation Army No. 150 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the efficacy of ceftazidime-avibactam (CZA) and aztreonam-avibactam (AZA) against bloodstream infections (BSIs) or lower respiratory tract infections (LRTIs) - caused by extensive drug-resistant or pan drug-resistant (XDR/PDR) Method: The two-fold dilution method was used to determine the minimum inhibitory concentrations (MICs) of CZA/AZA against XDR/PDR Results: We found that XDR/PDR P. aeruginosa may carry some rare MBLs (e.g.: IND-6, SLB-1, THIN-B). Conclusion: AZA has been considered as an option for the treatment of infections caused by XDR/PDR

Indexed as

Pseudomonas InfectionsRespiratory Tract InfectionsSepsisAnti-Bacterial AgentsAzabicyclo CompoundsAztreonambeta-LactamasesCeftazidimeDrug CombinationsHumansMicrobial Sensitivity TestsPharmaceutical PreparationsPseudomonas aeruginosaAnti-Bacterial Agentsavibactamavibactam, ceftazidime drug combinationAzabicyclo CompoundsAztreonambeta-LactamasesCeftazidimeDrug CombinationsPharmaceutical Preparations173 aztreonam-avibactamceftazidime-avibactamextensively drug-resistant Pseudomonas aeruginosapan drug-resistant Pseudomonas aeruginosawhole-genome sequencing

Identifiers

PMID37457958
PMCPMC10338846
OpenAlexW4382393540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.