Evidence map›Paper›PMID 37457871›Full record

Article3 Biotech2023

Heterocyclic chalcone (

Maria Kueirislene Amancio Ferreira, Wendy Pascoal Oliveira Freitas, Italo Moura Barbosa, Matheus Nunes da Rocha, Antônio Wlisses da Silva, Emanuela de Lima Rebouças, Francisco Rogênio da Silva Mendes, Carlucio Roberto Alves, Paulo Iury Gomes Nunes, Márcia Machado Marinho and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in 3 Biotech, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Europium Metal Complex [Eu(dbm)Chemistry & biodiversity · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Maria Kueirislene Amancio FerreiraLaboratório de Química de Produtos Naturais-LQPNS, Universidade Estadual do Ceará, Programa de Pós-Graduação em Ciências Naturais, Fortaleza, CE Brazil.
Wendy Pascoal Oliveira FreitasLaboratório de Química de Produtos Naturais-LQPNS, Universidade Estadual do Ceará, Programa de Pós-Graduação em Ciências Naturais, Fortaleza, CE Brazil.
Italo Moura BarbosaLaboratório de Química de Produtos Naturais-LQPNS, Universidade Estadual do Ceará, Programa de Pós-Graduação em Ciências Naturais, Fortaleza, CE Brazil.
Matheus Nunes da RochaLaboratório de Química de Produtos Naturais-LQPNS, Universidade Estadual do Ceará, Programa de Pós-Graduação em Ciências Naturais, Fortaleza, CE Brazil.
Antônio Wlisses da SilvaPrograma de Doutorado em Biotecnologia, Rede Nordeste de Biotecnologia (RENORBIO), Fortaleza, CE Brazil.
Emanuela de Lima RebouçasPrograma de Doutorado em Biotecnologia, Rede Nordeste de Biotecnologia (RENORBIO), Fortaleza, CE Brazil.
Francisco Rogênio da Silva MendesPrograma de Pós-Graduação em Química Biologica, Universidade Regional do Cariri, Crato, CE Brasil.
Carlucio Roberto AlvesLaboratório de Sistemas de Nanotecnologia e BiomateriaisPrograma de Pós-Graduação em Ciências Naturais, Universidade Estadual do Ceará, Fortaleza, CE Brazil.
Paulo Iury Gomes NunesDepartamento de Fisiologia e Farmacologia Laboratório de Produtos Naturais, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE Brazil.
Márcia Machado MarinhoDepartamento de Química, Universidade Estadual Vale do Acaraú, Sobral, CE Brazil.
Roselayne Ferro FurtadoEmbrapa Agroindústria Tropical, Fortaleza, CE Brazil.
Flávia Almeida SantosDepartamento de Fisiologia e Farmacologia Laboratório de Produtos Naturais, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE Brazil.
Emmanuel Silva MarinhoLaboratório de Química de Produtos Naturais-LQPNS, Universidade Estadual do Ceará, Programa de Pós-Graduação em Ciências Naturais, Fortaleza, CE Brazil.
Jane Eire Silva Alencar de MenezesLaboratório de Química de Produtos Naturais-LQPNS, Universidade Estadual do Ceará, Programa de Pós-Graduação em Ciências Naturais, Fortaleza, CE Brazil.
Helcio Silva Dos SantosLaboratório de Química de Produtos Naturais-LQPNS, Universidade Estadual do Ceará, Programa de Pós-Graduação em Ciências Naturais, Fortaleza, CE Brazil.ORCID 0000-0001-5527-164X
Universidade Estadual do Ceará · BRCentro de Tecnologias Estratégicas do Nordeste · BRUniversidade Federal do Ceará · BRBrazilian Agricultural Research Corporation · BRState University of Vale do Acaraú · BRUniversidade Regional do Cariri · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes is a disease linked to pathologies, such as chronic inflammation, neuropathy, and pain. The synthesis by the Claisen-Schmidt condensation reaction aims to obtain medium to high yield chalconic derivatives. Studies for the synthesis of new chalcone molecules aim at the structural manipulation of aromatic rings, as well as the replacement of rings by heterocycles, and combination through chemical reactions of synthesized structures with other molecules, in order to enhance biological activity. A chalcone was synthesized and evaluated for its antinociceptive, anti-inflammatory and hypoglycemic effect in adult zebrafish. In addition to reducing nociceptive behavior, chalcone (40 mg/kg) reversed post-treatment-induced acute and chronic hyperglycemia and reduced carrageenan-induced abdominal edema in zebrafish. It also showed an inhibitory effect on NO production in J774A.1 cells. When compared with the control groups, the oxidative stress generated after chronic hyperglycemia and after induction of abdominal edema was significantly reduced by chalcone. Molecular docking simulations of chalcone with Cox -1, Cox-2, and TRPA1 channel enzymes were performed and indicated that chalcone has a higher affinity for the COX-1 enzyme and 4 interactions with the TRPA1 channel. Chalcone also showed good pharmacokinetic properties as assessed by ADMET. Supplementary Information: The online version contains supplementary material available at 10.1007/s13205-023-03696-8.

Indexed as

ChalconeMolecular dockingNatural productZebrafish

Identifiers

PMID37457871
PMCPMC10349009
OpenAlexW4384283332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.