Evidence map›Paper›PMID 37457651›Full record

ArticleInternational journal of physiology, pathophysiology and pharmacology2023

HIV-1 envelope protein gp120 modulation of glutamate effects on cortical neuronal synapses: implications for HIV-1-associated neuropathogenesis.

Jianuo Liu, Jinyan Xie, Debashis Dutta, Huangui Xiong

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of physiology, pathophysiology and pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jianuo LiuNeurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center Omaha, NE 68198-5880, USA.
Jinyan XieNeurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center Omaha, NE 68198-5880, USA.
Debashis DuttaNeurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center Omaha, NE 68198-5880, USA.
Huangui XiongNeurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center Omaha, NE 68198-5880, USA.
University of Nebraska Medical Center · USNanchang University · CN

Funding

K channel, NLRP3 inflammasome and Meth exacerbation of HANDR01DA050540 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI XIONG, HUANGUI HANK · 2019 to 2023
$2.1M
Microglial ion channels and HIV-1-associated dementiaR01NS077873 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI XIONG, HUANGUI HANK · 2012 to 2016
$1.8M
NIDA NIH HHS R01 DA050540NINDS NIH HHS R01 NS077873
6 · The paper itself

Abstract

Despite the introduction of combined antiretroviral therapy (cART) HIV-1 virus persists in the brain in a latent or restricted manner and viral proteins, such as gp120, continue to play a significant disease-inciting role. Gp120 is known to interact with

Indexed as

cortical neuronglutamateHIV-1 gp120neuromodulationNMDA receptorsEPSC

Identifiers

PMID37457651
PMCPMC10349318
OpenAlexW4384493318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.