Evidence map›Paper›PMID 37457471›Full record

ArticleACS omega2023

Exploring the 5-Substituted 2-Aminobenzothiazole-Based DNA Gyrase B Inhibitors Active against ESKAPE Pathogens.

Maša Sterle, Martina Durcik, Clare E M Stevenson, Sara R Henderson, Petra Eva Szili, Marton Czikkely, David M Lawson, Anthony Maxwell, Dominique Cahard, Danijel Kikelj and 7 more

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. NewRSC advances · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 4 countries.

Maša SterleFaculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia.ORCID https://orcid.org/0000-0003-3898-5194
Martina DurcikFaculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia.ORCID https://orcid.org/0000-0002-9218-1771
Clare E M StevensonDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K.
Sara R HendersonInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, U.K.ORCID https://orcid.org/0000-0003-2078-639X
Petra Eva SziliSynthetic and Systems Biology Unit, Biological Research Centre, Institute of Biochemistry, Szeged H-6726, Hungary.
Marton CzikkelySynthetic and Systems Biology Unit, Biological Research Centre, Institute of Biochemistry, Szeged H-6726, Hungary.
David M LawsonDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K.
Anthony MaxwellDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K.ORCID https://orcid.org/0000-0002-5756-6430
Dominique CahardCNRS UMR 6014 COBRA, Normandie Université, Mont Saint Aignan 76821, France.ORCID https://orcid.org/0000-0002-8510-1315
Danijel KikeljFaculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia.
Nace ZidarFaculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia.ORCID https://orcid.org/0000-0003-1905-0158
Csaba PalSynthetic and Systems Biology Unit, Biological Research Centre, Institute of Biochemistry, Szeged H-6726, Hungary.
Lucija Peterlin MašičFaculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia.ORCID https://orcid.org/0000-0003-0624-8472
Janez IlašFaculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia.ORCID https://orcid.org/0000-0002-0124-0474
Tihomir TomašičFaculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia.ORCID https://orcid.org/0000-0001-5534-209X
Andrej Emanuel CotmanFaculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia.ORCID https://orcid.org/0000-0003-2528-396X
Anamarija ZegaFaculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia.ORCID https://orcid.org/0000-0003-4065-0019
University of Ljubljana · SIHUN-REN Szegedi Biológiai Kutatóközpont · HUJohn Innes Centre · GBCentre National de la Recherche Scientifique · FRUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a new series of 2-aminobenzothiazole-based DNA gyrase B inhibitors with promising activity against ESKAPE bacterial pathogens. Based on the binding information extracted from the cocrystal structure of DNA gyrase B inhibitor

Identifiers

PMID37457471
PMCPMC10339456
OpenAlexW4382726900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.