Evidence map›Paper›PMID 37457331›Full record

ArticleNational science review2023

3D micropattern force triggers YAP nuclear entry by transport across nuclear pores and modulates stem cells paracrine.

Yan Li, Zhenyu Zhong, Cunjing Xu, Xiaodan Wu, Jiaqi Li, Weiyong Tao, Jianglin Wang, Yingying Du, Shengmin Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in National science review, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Review
  3. 3D-bioprinted adipose-derived stem cell-secreted GAS6Journal of nanobiotechnology · 2026
    Article
  4. Review
  5. Structure, function and assembly of nuclear pore complexes.Nature reviews. Molecular cell biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yan LiAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan430074, China.
Zhenyu ZhongAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan430074, China.
Cunjing XuAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan430074, China.
Xiaodan WuAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan430074, China.
Jiaqi LiAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan430074, China.
Weiyong TaoAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan430074, China.
Jianglin WangAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan430074, China.
Yingying DuAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan430074, China.
Shengmin ZhangAdvanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan430074, China.
Huazhong University of Science and Technology · CNNational Medical Products Administration · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biophysical cues of the cellular microenvironment tremendously influence cell behavior by mechanotransduction. However, it is still unclear how cells sense and transduce the mechanical signals from 3D geometry to regulate cell function. Here, the mechanotransduction of human mesenchymal stem cells (MSCs) triggered by 3D micropatterns and its effect on the paracrine of MSCs are systematically investigated. Our findings show that 3D micropattern force could influence the spatial reorganization of the cytoskeleton, leading to different local forces which mediate nucleus alteration such as orientation, morphology, expression of Lamin A/C and chromatin condensation. Specifically, in the triangular prism and cuboid micropatterns, the ordered F-actin fibers are distributed over and fully transmit compressive forces to the nucleus, which results in nuclear flattening and stretching of nuclear pores, thus enhancing the nuclear import of YES-associated protein (YAP). Furthermore, the activation of YAP significantly enhances the paracrine of MSCs and upregulates the secretion of angiogenic growth factors. In contrast, the fewer compressive forces on the nucleus in cylinder and cube micropatterns cause less YAP entering the nucleus. The skin repair experiment provides the first

Indexed as

3D micropattern forcebioactive materialsmechanotransductionparacrinetissue regeneration

Identifiers

PMID37457331
PMCPMC10347367
OpenAlexW4379185242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.