Evidence map›Paper›PMID 37457323›Full record

ArticleVaccine: X2023

Ensuring vaccine safety: Case studies of falsified influenza vaccines detected in Brazil.

Jaline Alves Cabral da Costa, Maria de Lourdes Aguiar-Oliveira, David Brown, Jorge Antonio Zepeda Bermudez, Eduardo Jorge Rabelo Netto, Ozéias de Lima Leitão, Antonio Eugenio Castro Cardoso de Almeida, Marilda Mendonça Siqueira

Abstract read
In one paragraph

Article in Vaccine: X, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jaline Alves Cabral da CostaNational National Institute for Quality Control in Health (INCQS), Oswaldo Cruz Foundation, Av. Brazil, 4365, Manguinhos, Rio de Janeiro CEP 21040-360, Brazil.
Maria de Lourdes Aguiar-OliveiraLaboratory of Respiratory Virus and Measles, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Av. Brazil, 4365, Manguinhos, Rio de Janeiro CEP 21040-360, Brazil.
David BrownLaboratory of Respiratory Virus and Measles, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Av. Brazil, 4365, Manguinhos, Rio de Janeiro CEP 21040-360, Brazil.
Jorge Antonio Zepeda BermudezSergio Arouca National School of Public Health (ENSP), Oswaldo Cruz Foundation, Av. Brazil, 4365, Manguinhos, Rio de Janeiro CEP 21040-360, Brazil.
Eduardo Jorge Rabelo NettoNational National Institute for Quality Control in Health (INCQS), Oswaldo Cruz Foundation, Av. Brazil, 4365, Manguinhos, Rio de Janeiro CEP 21040-360, Brazil.
Ozéias de Lima LeitãoNational National Institute for Quality Control in Health (INCQS), Oswaldo Cruz Foundation, Av. Brazil, 4365, Manguinhos, Rio de Janeiro CEP 21040-360, Brazil.
Antonio Eugenio Castro Cardoso de AlmeidaNational National Institute for Quality Control in Health (INCQS), Oswaldo Cruz Foundation, Av. Brazil, 4365, Manguinhos, Rio de Janeiro CEP 21040-360, Brazil.
Marilda Mendonça SiqueiraLaboratory of Respiratory Virus and Measles, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Av. Brazil, 4365, Manguinhos, Rio de Janeiro CEP 21040-360, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Falsifications related to health technologies-including vaccines-are a growing threat to patient safety and health systems on a global scale and can cause serious harm to the population (especially vulnerable groups). In Brazil, the manufacturing and spread of counterfeit medicines are prevented through joint actions between different government agencies. In this study, we analyzed three cases of influenza vaccines suspected of counterfeiting. The samples were seized by officials and received by the National Institute for Quality Control in Health (INCQS), the national quality control reference laboratory of the Ministry of Health of Brazil, in 2010, 2017, and 2020. We report the results of our analytical investigations and emphasize the importance of strengthening the partnerships between various national agencies. The seized samples were visually inspected, and their information was compared with that of genuine vaccines (as recorded in the INCQS database). The specific analytical tests were based on quality control tests for biological products. Our results confirmed that all seized samples were falsified. We emphasize the importance of fostering international and intra-national collaborations between various national agencies (such as drug regulatory authorities, official laboratories, customs departments, police forces, and civil society). As demonstrated here, such collaborative actions are essential for combating the release of falsified medical products, safeguarding public health, and strengthening health systems.

Indexed as

BrazilFalsified vaccineInfluenza vaccinePublic healthQuality control

Identifiers

PMID37457323
PMCPMC10339189

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.