Evidence map›Paper›PMID 37457308›Full record

ArticleJournal of orthopaedic translation2023

Platelet-derived extracellular vesicles formulated with hyaluronic acid gels for application at the bone-implant interface: An animal study.

Miquel Antich-Rosselló, Maria Antònia Forteza-Genestra, Hans Jacob Ronold, Staale Petter Lyngstadaas, Mario García-González, María Permuy, Mónica López-Peña, Fernando Muñoz, Marta Monjo, Joana M Ramis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic translation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Miquel Antich-RossellóCell Therapy and Tissue Engineering Group, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands (UIB), Ctra. Valldemossa Km 7.5, 07122, Palma, Spain.
Maria Antònia Forteza-GenestraCell Therapy and Tissue Engineering Group, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands (UIB), Ctra. Valldemossa Km 7.5, 07122, Palma, Spain.
Hans Jacob RonoldDepartment of Prosthetic Dentistry, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.
Staale Petter LyngstadaasDepartment of Biomaterials, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.
Mario García-GonzálezDepartamento de Ciencias Clínicas Veterinarias. Universidade de Santiago de Compostela. Campus Universitario S/n, 27002, Lugo, Spain.
María PermuyIBoneLab SL, Avenida da Coruña 500; 27003, Lugo, Spain.
Mónica López-PeñaDepartamento de Ciencias Clínicas Veterinarias. Universidade de Santiago de Compostela. Campus Universitario S/n, 27002, Lugo, Spain.
Fernando MuñozDepartamento de Ciencias Clínicas Veterinarias. Universidade de Santiago de Compostela. Campus Universitario S/n, 27002, Lugo, Spain.
Marta MonjoCell Therapy and Tissue Engineering Group, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands (UIB), Ctra. Valldemossa Km 7.5, 07122, Palma, Spain.
Joana M RamisCell Therapy and Tissue Engineering Group, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands (UIB), Ctra. Valldemossa Km 7.5, 07122, Palma, Spain.
Health Research Institute of the Balearic Islands · ESUniversidade da Coruña · ESUniversity of Oslo · NOUniversidade de Santiago de Compostela · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Objective: Platelet derived extracellular vesicles (pEV) are promising therapeutical tools for bone healing applications. In fact, several Methods: Here, we used hyaluronic acid (HA) gels formulated with pEVs, as a way to directly apply pEVs and retain them at the bone defect. In this study, pEVs were isolated from Platelet Lysate (PL) through size exclusion chromatography and used to formulate 2% HA gels. Then, the gels were locally applied on the tibia cortical bone defect of New Zeland White rabbits before the surgical implantation of coin-shaped titanium implants. After eight weeks, the bone healing process was analyzed through biomechanical, micro-CT, histological and biochemical analysis. Results: Although no biomechanical differences were observed between pEV formulated gels and non-formulated gels, biochemical markers of the wound fluid at the interface presented a decrease in Lactate dehydrogenase (LDH) activity and alkaline phosphatase (ALP) activity for pEV HA treated implants. Moreover, histological analyses showed that none of the treatments induced an irritative effect and, a decrease in the fibrotic response surrounding the implant for pEV HA treated implants was described. Conclusion: In conclusion, pEVs improve titanium implants biocompatibility at the bone-implant interface, decreasing the necrotic effects of the surgery and diminishing the fibrotic layer associated to the implant encapsulation that can lead to implant failure.

Indexed as

Bone regenerationExtracellular vesiclesHyaluronic acidPlateletsTitanium implants

Identifiers

PMID37457308
PMCPMC10338901
OpenAlexW4380200568

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.