Evidence map›Paper›PMID 37456579›Full record

ArticleBioactive materials2023

A metal ions-mediated natural small molecules carrier-free injectable hydrogel achieving laser-mediated photo-Fenton-like anticancer therapy by synergy apoptosis/cuproptosis/anti-inflammation.

Wenmin Pi, Linying Wu, Jihui Lu, Xiaoyu Lin, Xuemei Huang, Zhijia Wang, Zhihua Yuan, Hailing Qiu, Jianglan Zhang, Haimin Lei and 1 more

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
35.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Advances in carrier-free nanodrug delivery systems.Drug delivery and translational research · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Injectable ZnMaterials today. Bio · 2026
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Harnessing Cuproptosis resistance to advance cancer therapeutics.Apoptosis : an international journal on programmed cell death · 2026
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Wenmin PiSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China.
Linying WuSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China.
Jihui LuSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China.
Xiaoyu LinSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China.
Xuemei HuangSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China.
Zhijia WangSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China.
Zhihua YuanSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China.
Hailing QiuSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China.
Jianglan ZhangSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, China.
Haimin LeiSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China.
Penglong WangSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China.
Beijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor microenvironment (TME) plays an important role in the tumorigenesis, proliferation, invasion and metastasis. Thereby developing synergistic anticancer strategies with multiple mechanisms are urgent. Copper is widely used in the treatment of tumor chemodynamic therapy (CDT) due to its excellent laser-mediated photo-Fenton-like reaction. Additionally, copper can induce cell death through cuproptosis, which is a new modality different from the known death mechanisms and has great promise in tumor treatment. Herein, we report a natural small molecules carrier-free injectable hydrogel (NCTD Gel) consisted of Cu

Indexed as

CuproptosisLaser-mediated photo-fenton-like reactionNatural small molecular ternary carrier-free hydrogelTumor microenvironment

Identifiers

PMID37456579
PMCPMC10345197
OpenAlexW4383213660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.