Evidence map›Paper›PMID 37456358›Full record

ArticleJournal of pain research2023

Genetic Factors Associated with Morphine Consumption in Women Undergoing Laparoscopic Cholecystectomy: A Prospective Cohort Study.

Hamed M Elgendy, Sami M Ibrahim, Loulia Bader, Rudaina A Mohammad, Zainab O Ali, Mohamed Ben Allala Bejaoui, Mohamad Hilani, Hesham Ismail, Hazem F Elewa

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pain research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04621864 (Can Gene Polymorphisms Influence Morphine Analgesic Consumption After Laparoscopic Cholecystectomy? A Prospective Cohort Study.), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04621864 completednot on this map

Can Gene Polymorphisms Influence Morphine Analgesic Consumption After Laparoscopic Cholecystectomy? A Prospective Cohort Study.

TypeobservationalSponsorHamad Medical CorporationRan2020 to 2022Enrolled300ConditionsGene, Polymorphosis
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Hamed M ElgendyDepartment of Anaesthesia, Hamad Medical Corporation, Doha, Qatar.ORCID 0000-0002-3887-0226
Sami M IbrahimDepartment of Anaesthesia, Hamad Medical Corporation, Doha, Qatar.
Loulia BaderCollege of Pharmacy, QU Health, Qatar University, Doha, Qatar.
Rudaina A MohammadHamad Medical Corporation, Medical Research Center, Doha, Qatar.
Zainab O AliHamad Medical Corporation, Medical Research Center, Doha, Qatar.
Mohamed Ben Allala BejaouiHamad Medical Corporation, Medical Research Center, Doha, Qatar.
Mohamad HilaniDepartment of Anaesthesia, Hamad Medical Corporation, Doha, Qatar.
Hesham IsmailDepartment of Anaesthesia, Hamad Medical Corporation, Doha, Qatar.
Hazem F ElewaCollege of Pharmacy, QU Health, Qatar University, Doha, Qatar.ORCID 0000-0003-1594-1199
Hamad Medical Corporation · QAQatar University · QAAssiut University Hospitals · EGZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Morphine has been a crucial analgesic agent used perioperatively in various surgical procedures. Genetic factors can lead to morphine dose requirement interpatient variability. Our objective was to determine the contribution of genetic polymorphisms in human μ-opioid receptor gene (OPRM1), ATP binding cassette gene (ABCB1) and rs2952768 to the variation of the perioperative morphine consumption in women undergoing laparoscopic cholecystectomy. Methods: This is a prospective cohort study that included 102 adult Arab females undergoing laparoscopic cholecystectomy. The exposures were carrying the genetic variants of Results: Both (rs1799971, A>G) in Conclusion: Clinical Trial Identifier: This study was registered at ClinicalTrials.gov, NCT04621864. https://clinicaltrials.gov/ct2/show/NCT04621864.

Indexed as

ABCB1Arabsgenetic polymorphismsopioidOPRM1post-operative painwomen

Identifiers

PMID37456358
PMCPMC10349379
OpenAlexW4384408260

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.