ArticleQuantitative imaging in medicine and surgery2023
Morphology of hypertrophied basal septum contributes to left ventricular outflow tract obstruction in patients with hypertrophic cardiomyopathy: a retrospective case-control study.
Article in Quantitative imaging in medicine and surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Detection of latent obstruction in patients with hypertrophic cardiomyopathy using parameters derived from resting echocardiography.Quantitative imaging in medicine and surgery · 2025Article
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6 authors at 2 institutions in 1 country.
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Abstract
Background: Detailed assessment of basal septal morphology is essential for understanding the morphological mechanism of left ventricular outflow tract (LVOT) obstruction. We aimed to analyze the morphological alterations of the basal septum (BS) and its surrounding structures and explore their role in LVOT obstruction (LVOTO) in patients with hypertrophic cardiomyopathy (HCM). Methods: During January 2019 and December 2019, 239 patients were diagnosed with HCM at Fuwai Hospital. We retrospectively reviewed echocardiographic data sets from 105 consecutive patients with HCM [64 with hypertrophic obstructive cardiomyopathy (HOCM) and 41 with hypertrophic non-obstructive cardiomyopathy (HNOCM)] and 28 healthy controls. For quantitatively assessing the basal septal morphology, a novel measurement method was used to obtain the IVSa (the area of the BS protruding into the LVOT), L Results: There was no significant difference in the maximal basal septal thickness between the HOCM and HNOCM patients (P>0.99). Among the three groups, there were significant differences in the length of the anterior and posterior mitral leaflets (AML and PML), the angle between the mitral valve orifice and ascending aorta (MV-AO) angle, IVSa, L Conclusions: Morphological alterations of the BS relative to the LVOT may provide additional value for estimating the extent of LVOTO. The length of AML, MV-AO angle, IVSa, and S-IVSa were associated with LVOTO.
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