Evidence map›Paper›PMID 37456140›Full record

ArticleOxford open neuroscience2023

Theta oscillations in anterior cingulate cortex and orbitofrontal cortex differentially modulate accuracy and speed in flexible reward learning.

Tony Ye, Juan Luis Romero-Sosa, Anne Rickard, Claudia G Aguirre, Andrew M Wikenheiser, Hugh T Blair, Alicia Izquierdo

Abstract read
In one paragraph

Article in Oxford open neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Beta and High Gamma Oscillations in the Cortico-striatal Network Reflect Reward Certainty on a Probabilistic Reversal Learning Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  4. Review
  5. Neurostimulation to Improve Cognitive Flexibility.Current opinion in behavioral sciences · 2025
    Article
  6. Article
  7. Article
  8. Optogenetic Inhibition of Rat Anterior Cingulate Cortex Impairs the Ability to Initiate and Stay on Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  9. Article
  10. Dissociable Contributions of Basolateral Amygdala and Ventrolateral Orbitofrontal Cortex to Flexible Learning Under Uncertainty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tony YeDepartment of Psychology, UCLA, Los Angeles, CA 90095, USA.
Juan Luis Romero-SosaDepartment of Psychology, UCLA, Los Angeles, CA 90095, USA.
Anne RickardDepartment of Psychology, UCLA, Los Angeles, CA 90095, USA.
Claudia G AguirreDepartment of Psychology, UCLA, Los Angeles, CA 90095, USA.
Andrew M WikenheiserDepartment of Psychology, UCLA, Los Angeles, CA 90095, USA.
Hugh T BlairDepartment of Psychology, UCLA, Los Angeles, CA 90095, USA.
Alicia IzquierdoDepartment of Psychology, UCLA, Los Angeles, CA 90095, USA.

Funding

CRCNS Research Proposal: Cortico-amygdalar substrates of adaptive learningR01DA047870 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alicia Izquierdo, Alireza Soltani · 2018 to 2026
$4.1M
Training in Neurotechnology TranslationT32NS115753 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LU, DANIEL, MARKOVIC, DEJAN · 2020 to 2024
$1.2M
Frontocortical Signaling Signatures in Flexible Reinforcement LearningR21MH122800 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BLAIR, HUGH T, IZQUIERDO, ALICIA · 2021 to 2022
$429k
NIDA NIH HHS R01 DA047870NIMH NIH HHS R21 MH122800NINDS NIH HHS T32 NS115753
6 · The paper itself

Abstract

Flexible reward learning relies on frontal cortex, with substantial evidence indicating that anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC) subregions play important roles. Recent studies in both rat and macaque suggest theta oscillations (5-10 Hz) may be a spectral signature that coordinates this learning. However, network-level interactions between ACC and OFC in flexible learning remain unclear. We investigated the learning of stimulus-reward associations using a combination of simultaneous

Indexed as

DREADDs.oscillationsprefrontal cortexreversal learningtheta

Identifiers

PMID37456140
PMCPMC10348740

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.