Evidence map›Paper›PMID 37456138›Full record

ArticlemicroPublication biology2023

Co-culture with normal and senescent AC16 cardiomyocytes modulates fibrotic response in primary human ventricular fibroblasts.

Veronica Hidalgo, Nikhitha Kastury, Cheyanne W Durham, Jordan Currie, Milton Amaya, Maggie P Y Lam, Edward Lau

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in microPublication biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Veronica HidalgoMedicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Nikhitha KasturyMedicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Cheyanne W DurhamUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Jordan CurrieUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Milton AmayaUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Maggie P Y LamMedicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Edward LauMedicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
University of Colorado Anschutz Medical Campus · US

Funding

Multi-Omics Approach to Identify Cardiokines in Human iPSC ModelsR00HL144829 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI LAU, EDWARD · 2020 to 2022
$733k
NHLBI NIH HHS R00 HL144829
6 · The paper itself

Abstract

Transwell co-culture with human AC16 cardiomyocyte-like cells modifies the response of primary human ventricular fibroblasts to TGF-β stimulation. Fibrotic response markers including collagen I (COL1A1) and ɑ-smooth muscle actin (ACTA2) are amplified in the presence of AC16 cells, whereas others including periostin (POSTN) and fibronectin (FN1) are suppressed. Similar modulation is observed when the ventricular fibroblasts are co-cultured with AC16 cells under baseline and induced senescence conditions. Given that the response to TGF-β stimulation is commonly measured to study fibrotic signaling and drug treatments in vitro, the results here suggest that the effect of cellular crosstalk should be more broadly considered.

Identifiers

PMID37456138
PMCPMC10349648
OpenAlexW4384493427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.