Evidence map›Paper›PMID 37456020›Full record

ArticleHeliyon2023

Micheliolide attenuates neuroinflammation to improve cognitive impairment of Alzheimer's disease by inhibiting NF-κB and PI3K/Akt signaling pathways.

Guizhen Yang, You Hu, Xiangyang Qin, Jinxia Sun, Zhulei Miao, Lixin Wang, Zunji Ke, Yuejuan Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Guizhen YangThe Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
You HuThe Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Xiangyang QinDepartment of Chemistry, School of Pharmacy, Air Force Medical University, Xi'an, Shaanxi, 710032, China.
Jinxia SunDepartment of Immunology and Microbiology, School of Basic Medicine Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Zhulei MiaoDepartment of Immunology and Microbiology, School of Basic Medicine Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Lixin WangDepartment of Immunology and Microbiology, School of Basic Medicine Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Zunji KeInstitute of Integrative Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Yuejuan ZhengThe Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Shanghai University of Traditional Chinese Medicine · CNAir Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory reaction in the brain activates glial cells, and over-activated glial cells secrete inflammatory mediators, which aggravates the inflammatory response in the brain and accelerates the development of Alzheimer's disease (AD) in turn. Numerous natural compounds from herbs can alleviate inflammation, and it is very promising to find

Indexed as

Alzheimer's diseaseGlial cellsMicheliolideNeuro-inflammationNF-κBPI3K/Akt

Identifiers

PMID37456020
PMCPMC10344752
OpenAlexW4383093049

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.