Evidence map›Paper›PMID 37456012›Full record

ArticleHeliyon2023

Increased CaMKII activation and contrast changes of cardiac β1-and β3-Adrenergic signaling pathways in a humanized angiotensinogen model of hypertension.

Xiaoqiang Sun, Jing Cao, Zhe Chen, Yixi Liu, Jessica L VonCannon, Heng Jie Cheng, Carlos M Ferrario, Che Ping Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Xiaoqiang SunDepartment of Cardiology, Tianjin First Central Hospital, Tianjin, China.
Jing CaoDepartment of Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan, China.
Zhe ChenDepartment of Internal Medicine, Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Yixi LiuDepartment of Internal Medicine, Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Jessica L VonCannonDepartment of Surgery, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Heng Jie ChengDepartment of Internal Medicine, Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Carlos M FerrarioDepartment of Surgery, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Che Ping ChengDepartment of Internal Medicine, Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Wake Forest University · USCapital Medical University · CNKunming Medical University · CNNankai University · CNShanxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Upregulation of Ca Main methods: We compared LV myocyte CaMKIIδ, CaMKIIδ phosphorylation (at Thr287) (pCaMKIIδ), and β Key findings: Hypertension in TGR (hAGT)L1623 rats was accompanied by significantly increased LV myocyte β Significance: LV myocyte CaMKIIδ overactivation with associated contrast changes in β

Indexed as

AngiotensinogenCalcium-calmodulin-dependent protein kinase type IICardiomyocyteHeart failureHypertensionRenin-angiotensin systemTransgenic modelsβ-adrenergic reserve

Identifiers

PMID37456012
PMCPMC10344767
OpenAlexW4382651857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.