ArticleJournal of clinical neurology (Seoul, Korea)2023
Predicting Sumatriptan Responsiveness Based on Structural Connectivity in Patients Newly Diagnosed With Migraine.
Article in Journal of clinical neurology (Seoul, Korea), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Brain network properties in chronic pain-a systematic review and meta-analysis of graph-based connectivity metrics.Frontiers in neuroscience · 2025Pooled it
- Artificial Intelligence That Changes Clinical Neurology Practice: Translating Algorithms Into Actionable Care.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Association Between Small Vessel Disease and Migraine: A Study Based on Peak Width of Skeletonized Mean Diffusivity.Journal of clinical neurology (Seoul, Korea) · 2025Article
- The association between structural connectivity and anti-seizure medication response in patients with temporal lobe epilepsy.Epilepsia open · 2024Article
- Alteration of multilayer network perspective on gray and white matter connectivity in obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Integrating Structural and Functional Connectivities of Neural Networks: A Comprehensive Approach for Advancing Neuroscience.Journal of clinical neurology (Seoul, Korea) · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeWe aimed to determine whether structural brain connectivity is significantly associated with the response to sumatriptan in patients with migraine.
methodsWe retrospectively enrolled patients with newly diagnosed migraine who underwent brain diffusion-tensor imaging (DTI) at the time of diagnosis, with regular follow-up for at least 6 months after the initial diagnosis. Patients were classified into good- and poor-responder groups according to their response to sumatriptan. We analyzed the structural connectivity using DTI by applying graph theory using DSI Studio software.
resultsWe enrolled 59 patients (35 good responders and 24 poor responders) and 30 healthy controls. Global structural connectivity differed significantly between patients with migraine and healthy controls, while local structural connectivity differed significantly between good and poor responders. The betweenness centrality was lower in good responders than in poor responders in the left lateral geniculate thalamic nucleus (26.078 vs. 41.371,
conclusionsWe found that structural connectivity in patients with migraine differed from that in healthy controls. Moreover, the local structural connectivity varied with the response to sumatriptan, which suggests that structural connectivity is a useful factor for predicting how a patient will respond to sumatriptan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.