Evidence map›Paper›PMID 37455296›Full record

ArticleIntensive care medicine experimental2023

Serum proteome profiles in patients treated with targeted temperature management after out-of-hospital cardiac arrest.

Gabriele Lileikyte, Anahita Bakochi, Ashfaq Ali, Marion Moseby-Knappe, Tobias Cronberg, Hans Friberg, Gisela Lilja, Helena Levin, Filip Årman, Sven Kjellström and 4 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine experimental, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07017374 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Proteomic Analysis of Serum Samples After Cardiac Arrest: a TTM-trial Substudy

TypeobservationalSponsorRegion SkaneRan2025 to 2026Enrolled682ConditionsCardiac Arrest (CA), ProteomicsArmsProteomic analysis, targeted temperature management
NCT07090577 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Serial Multiomics Profiling Using Serum and Cerebrospinal Fluid Samples Following Out-of-hospital Cardiac Arrest: a Prospective Observational Study

TypeobservationalSponsorChungnam National University HospitalRan2025 to 2026Enrolled15ConditionsCardiac Arrest (CA), Hypoxic-Ischemic Brain Injury, Post-Resuscitation Syndrome
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Multiomic biomarkers after cardiac arrest.Intensive care medicine experimental · 2024
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Gabriele LileikyteDepartment of Clinical Sciences Lund, Anaesthesia and Intensive Care, Lund University, Helsingborg Hospital, Svartbrödragränden 3, 251 87, Helsingborg, Sweden. gabriele.lileikyte@med.lu.se.ORCID http://orcid.org/0000-0002-6778-6269
Anahita BakochiSwedish National Infrastructure for Biological Mass Spectrometry (BioMS), Lund University, Lund, Sweden.
Ashfaq AliNational Bioinformatics Infrastructure Sweden (NBIS), SciLifeLab, Department of Immunotechnology, Lund University, Lund, Sweden.
Marion Moseby-KnappeDepartment of Clinical Sciences Lund, Neurology, Lund University, Skåne University Hospital, Lund, Sweden.
Tobias CronbergDepartment of Clinical Sciences Lund, Neurology, Lund University, Skåne University Hospital, Lund, Sweden.
Hans FribergDepartment of Clinical Sciences Lund, Anaesthesia and Intensive Care, Lund University, Skåne University Hospital, Malmö, Sweden.
Gisela LiljaDepartment of Clinical Sciences Lund, Neurology, Lund University, Skåne University Hospital, Lund, Sweden.
Helena LevinDepartment of Clinical Sciences Lund, Department of Research and Education, Lund University, Skåne University Hospital, Lund, Sweden.
Filip ÅrmanSwedish National Infrastructure for Biological Mass Spectrometry (BioMS), Lund University, Lund, Sweden.
Sven KjellströmSwedish National Infrastructure for Biological Mass Spectrometry (BioMS), Lund University, Lund, Sweden.
Josef DankiewiczDepartment of Clinical Sciences Lund, Cardiology, Lund University, Skåne University Hospital, Lund, Sweden.
Christian HassagerDepartment of Cardiology, Rigshospitalet and Dept of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Johan MalmströmDepartment of Clinical Sciences Lund, Infection Medicine, Lund University, Lund, Sweden.
Niklas NielsenDepartment of Clinical Sciences Lund, Anaesthesia and Intensive Care, Lund University, Helsingborg Hospital, Svartbrödragränden 3, 251 87, Helsingborg, Sweden.
Lund University · SEUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDefinition of temporal serum proteome profiles after out-of-hospital cardiac arrest may identify biological processes associated with severe hypoxia-ischaemia and reperfusion. It may further explore intervention effects for new mechanistic insights, identify candidate prognostic protein biomarkers and potential therapeutic targets. This pilot study aimed to investigate serum proteome profiles from unconscious patients admitted to hospital after out-of-hospital cardiac arrest according to temperature treatment and neurological outcome.

methodsSerum samples at 24, 48, and 72 h after cardiac arrest at three centres included in the Target Temperature Management after out-of-hospital cardiac arrest trial underwent data-independent acquisition mass spectrometry analysis (DIA-MS) to find changes in serum protein concentrations associated with neurological outcome at 6-month follow-up and targeted temperature management (TTM) at 33 °C as compared to 36 °C. Neurological outcome was defined according to Cerebral Performance Category (CPC) scale as "good" (CPC 1-2, good cerebral performance or moderate disability) or "poor" (CPC 3-5, severe disability, unresponsive wakefulness syndrome, or death).

resultsOf 78 included patients [mean age 66 ± 12 years, 62 (80.0%) male], 37 (47.4%) were randomised to TTM at 36 °C. Six-month outcome was poor in 47 (60.3%) patients. The DIA-MS analysis identified and quantified 403 unique human proteins. Differential protein abundance testing comparing poor to good outcome showed 19 elevated proteins in patients with poor outcome (log

conclusionsSerum proteome profiling revealed an increase in inflammatory/immune responses and apoptosis in patients with poor outcome. In patients with good outcome, an increase in proteolysis was observed, whereas TTM-level only had a modest effect on the proteome profiles. Further validation of the differentially abundant proteins in response to neurological outcome is necessary to validate novel biomarker candidates that may predict prognosis after cardiac arrest.

Indexed as

Heart arrestHypothermiaOut-of-hospital cardiac arrestPrognosticationProteomicsTargeted temperature managementTemperature control

Identifiers

PMID37455296
PMCPMC10350448
OpenAlexW4384486006

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.