ReviewInternal and emergency medicine2023
Metabolic dysfunction-associated gallstone disease: expecting more from critical care manifestations.
Review in Internal and emergency medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Exploring the gut-exercise link: A systematic review of gastrointestinal disorders in physical activity.World journal of gastroenterology · 2025Pooled it
- Review
- Age-related vulnerability and clinical outcomes in acute pancreatitis: a stratified cohort study of 1,034 patients.BMC gastroenterology · 2026Article
- Bempedoic acid within the phase ternary diagram governing biliary cholesterol solubilization and gallstone risk.Journal of lipid research · 2026Review
- Dietary fiber intake and gallstones: The mediating role of serum lipids.The Journal of international medical research · 2026Article
- An elderly female with a large haematoma-like abdominal abscess. All that glitters is not gold.Internal and emergency medicine · 2026Article
- A nomogram for estimating prevalent gallstone risk in patients with type 2 diabetes: development and validation in a multicenter cohort.BMC endocrine disorders · 2026Article
- Associations between lipid accumulation indices and gallstone prevalence in Chinese elderly: a community-based study in Fuzhou.BMC gastroenterology · 2026Article
- Aquaporin membrane channels in the hepatobiliary tract: a model of complexity and clinical implications in health and disease.Internal and emergency medicine · 2026Review
- Article
- Gut Microbiota-Bile Acid Axis in Type 2 Diabetes-Associated Gallbladder Diseases: Mechanisms and Therapeutic Potential.Metabolites · 2026Review
- Radiomics analysis based on MRCP for predicting post-ERCP pancreatitis in patients with common bile duct stones.Surgical endoscopy · 2026Article
- Gut microbiota-derived short-chain fatty acids in gallstones: mechanisms and intervention strategies.Frontiers in microbiology · 2026Review
- Development and validation of gallstone disease risk factor identification model: a cross-sectional study in Western China.Frontiers in nutrition · 2026Article
- BILIARY SLUDGE-ASSOCIATED ACUTE PANCREATITIS: CLINICAL SPECTRUM, DIAGNOSIS, AND MANAGEMENT.Arquivos de gastroenterologia · 2026Review
- Cystic Artery Hemorrhage as a Rare Complication of Acute Gangrenous Cholecystitis.International medical case reports journal · 2026Article
- Article
- Melatonin's anti-inflammatory and antioxidant effects in gallstone disease: A narrative review.World journal of hepatology · 2025Review
- Non-contact measurement of glucose in urine by smartphone-based laser refractometry for diabetes monitoring.Scientific reports · 2025Article
- Diagnostic Value of Multimodal Imaging and Histopathology in Gallstone Ileus: A Retrospective Analysis.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
About 20% of adults worldwide have gallstones which are solid conglomerates in the biliary tree made of cholesterol monohydrate crystals, mucin, calcium bilirubinate, and protein aggregates. About 20% of gallstone patients will definitively develop gallstone disease, a condition which consists of gallstone-related symptoms and/or complications requiring medical therapy, endoscopic procedures, and/or cholecystectomy. Gallstones represent one of the most prevalent digestive disorders in Western countries and patients with gallstone disease are one of the largest categories admitted to European hospitals. About 80% of gallstones in Western countries are made of cholesterol due to disturbed cholesterol homeostasis which involves the liver, the gallbladder and the intestine on a genetic background. The incidence of cholesterol gallstones is dramatically increasing in parallel with the global epidemic of insulin resistance, type 2 diabetes, expansion of visceral adiposity, obesity, and metabolic syndrome. In this context, gallstones can be largely considered a metabolic dysfunction-associated gallstone disease, a condition prone to specific and systemic preventive measures. In this review we discuss the key pathogenic and clinical aspects of gallstones, as the main clinical consequences of metabolic dysfunction-associated disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.