Evidence map›Paper›PMID 37455161›Full record

ArticleVaccine2023

A humanized monoclonal antibody targeting protein a promotes opsonophagocytosis of Staphylococcus aureus in human umbilical cord blood.

Paola Nol Bernardino, Mohini Bhattacharya, Xinhai Chen, Julia Jenkins, Dominique Missiakas, Vilasack Thammavongsa

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Paola Nol BernardinoThe University of Chicago, Department of Microbiology, Howard Taylor Ricketts Laboratory, Lemont, IL 60439, USA.
Mohini BhattacharyaThe University of Chicago, Department of Microbiology, Howard Taylor Ricketts Laboratory, Lemont, IL 60439, USA.
Xinhai ChenThe University of Chicago, Department of Microbiology, Howard Taylor Ricketts Laboratory, Lemont, IL 60439, USA.
Julia JenkinsThe University of Chicago, Department of Microbiology, Howard Taylor Ricketts Laboratory, Lemont, IL 60439, USA.
Dominique MissiakasThe University of Chicago, Department of Microbiology, Howard Taylor Ricketts Laboratory, Lemont, IL 60439, USA.
Vilasack ThammavongsaIMMUNARTES LLC, 400 N Aberdeen St, STE 900, Chicago, IL 60642, USA. Electronic address: vthammavongsa@immunartes.com.
University of Chicago · USImmune Regulation (United Kingdom) · GB

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1M
Engineering monoclonal antibodies against Staphylococcus aureusR01AI148543 · NIAID · UNIVERSITY OF CHICAGO · PI Dominique Missiakas · 2020 to 2026
$5.5M
NCI NIH HHS P30 CA014599NIAID NIH HHS R01 AI148543
6 · The paper itself

Abstract

Low and very-low-birth-weight (V/LBW) neonates are highly susceptible to bacterial sepsis and meningitis. Bacterial infections caused by Staphylococcus aureus can be particularly dangerous for neonates and can result in high mortality and long-term disabilities.Antibody-based strategies have been attempted to protect V/LBW neonates against staphylococcal disease. However, these efforts have so far been unsuccessful. Failures were attributed to the immaturity of the neonatal immune system but did not account for the anti-opsonic activity of Staphylococcal protein A (SpA). Here we show that monoclonal antibody 3F6, which blocks SpA activity, promotes complement-dependent cell-mediated phagocytosis of S. aureus in human umbilical cord blood. A substitution in the crystallizable fragment (Fc) region of 3F6 that enhances recruitment of complement component C1q further increases the phagocytic activity of cord blood. Our data demonstrate that the neonatal immune system possesses bactericidal activity that can be harnessed by antibodies that circumvent a key innate immune strategy of S. aureus.

Indexed as

Staphylococcal InfectionsStaphylococcus aureusAntibodies, BacterialAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedFetal BloodHumansInfant, NewbornOpsonizationStaphylococcal Protein AAntibodies, BacterialAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedStaphylococcal Protein AAntibody-mediated opsonophagocytosisMonoclonal antibodyNeonatal bacteremia/meningitisStaphylococcal protein AStaphylococcus aureusUmbilical cord blood

Identifiers

PMID37455161
PMCPMC10412981
OpenAlexW4384470622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.