Evidence map›Paper›PMID 37454931›Full record

ReviewAdvanced drug delivery reviews2023

Towards single cell encapsulation for precision biology and medicine.

Prerak Gupta, Omar Alheib, Jae-Won Shin

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Prerak GuptaDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA; Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
Omar Alheib3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães 4805-017, Portugal.
Jae-Won ShinDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA; Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA. Electronic address: shinjw@uic.edu.

Funding

Encapsulation of mesenchymal stromal cells in engineered microgels for resolution of lung fibrosisR01HL141255 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHIN, JAE-WON · 2019 to 2023
$2.0M
Engineering microscale hydrogel deposition to direct single stem cell differentiationR01GM141147 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHIN, JAE-WON · 2021 to 2024
$1.9M
Therapeutic nanoscale matrimeresR01EB034507 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHIN, JAE-WON · 2023 to 2025
$1.3M
NHLBI NIH HHS R01 HL141255NIBIB NIH HHS R01 EB034507NIGMS NIH HHS R01 GM141147
6 · The paper itself

Abstract

The primary impetus of therapeutic cell encapsulation in the past several decades has been to broaden the options for donor cell sources by countering against immune-mediated rejection. However, another significant advantage of encapsulation is to provide donor cells with physiologically relevant cues that become compromised in disease. The advances in biomaterial design have led to the fundamental insight that cells sense and respond to various signals encoded in materials, ranging from biochemical to mechanical cues. The biomaterial design for cell encapsulation is becoming more sophisticated in controlling specific aspects of cellular phenotypes and more precise down to the single cell level. This recent progress offers a paradigm shift by designing single cell-encapsulating materials with predefined cues to precisely control donor cells after transplantation.

Indexed as

Biocompatible MaterialsCell EncapsulationBiologyHumansBiocompatible MaterialsCell therapyExtracellular matrixMicroencapsulationPrecision medicineSingle cell biologySingle cell encapsulation

Identifiers

PMID37454931
PMCPMC10798218

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.