ArticleStereotactic and functional neurosurgery2023
Preliminary Experience with a Four-Lead Implantable Pulse Generator for Deep Brain Stimulation.
Article in Stereotactic and functional neurosurgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Using Multinodal Deep Brain Stimulation for Treatment of Complex Movement Disorders: Initial Case Series.Operative neurosurgery (Hagerstown, Md.) · 2026Article
- Thalamocortical network neuromodulation for epilepsy.Brain communications · 2025Article
- Canonical Response Parameterization: Quantifying the structure of responses to single-pulse intracranial electrical brain stimulation.PLoS computational biology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundImplantable pulse generators (IPGs) store energy and deliver electrical impulses for deep brain stimulation (DBS) to treat neurological and psychiatric disorders. IPGs have evolved over time to meet the demands of expanding clinical indications and more nuanced therapeutic approaches.
objectivesThe aim of this study was to examine the workflow of the first 4-lead IPG for DBS in patients with complex disease.
methodThe engineering capabilities, clinical use cases, and surgical technique are described in a cohort of 12 patients with epilepsy, essential tremor, Parkinson's disease, mixed tremor, and Tourette's syndrome with comorbid obsessive-compulsive disorder between July 2021 and July 2022.
resultsThis system is a rechargeable 32-channel, 4-port system with independent current control that can be connected to 8 contact linear or directionally segmented leads. The system is ideal for patients with mixed disease or those with multiple severe symptoms amenable to >2 lead implantations. A multidisciplinary team including neurologists, radiologists, and neurosurgeons is necessary to safely plan the procedure. There were no serious intraoperative or postoperative adverse events. One patient required revision surgery for bowstringing.
conclusionsThis new 4-lead IPG represents an important new tool for DBS surgery with the ability to expand lead implantation paradigms for patients with complex disease.
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Registered trials
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