Evidence map›Paper›PMID 37454358›Full record

ArticleArchives of osteoporosis2023

Hip structural analysis, trabecular bone score, and bone mineral density in post-menopausal women with type-2 diabetes mellitus: a multi-center cross-sectional study in the south of Iran.

Arzhang Naseri, Ehsan Shojaeefard, Marzieh Bakhshayeshkaram, Mohammad Mahdi Dabbaghmanesh, Seyed Taghi Heydari, Pedram Talezadeh, Mostafa Farhadi, Alireza Nikkhah, Mohammad Hossein Dabbaghmanesh

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Archives of osteoporosis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Bone microstructure and TBS in diabetes: what have we learned? A narrative review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Arzhang NaseriEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0002-4095-2351
Ehsan ShojaeefardEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0002-7473-4424
Marzieh BakhshayeshkaramEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Mahdi DabbaghmaneshEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed Taghi HeydariHealth Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Pedram TalezadehEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mostafa FarhadiEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0001-7673-0040
Alireza NikkhahEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0001-9198-9763
Mohammad Hossein DabbaghmaneshEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. dabbaghm@sums.ac.ir.
Shiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate bone mineral density (BMD), trabecular microarchitecture, and proximal hip geometry in diabetic postmenopausal women, where BMD alone cannot reflect bone strength adequately. We found significantly lower trabecular bone score and BMD at the distal radius and total forearm in diabetic subjects compared to controls. PURPOSE: The limitations resulting from the exclusive assessment of bone mineral density (BMD) in people with diabetes can lead to underestimation of microarchitectural and geometric changes, both of which play an essential role in the fracture risk. Therefore, we aimed to evaluate BMD, trabecular bone score (TBS), and hip structural analysis (HSA) in diabetic type-2 post-menopausal women and compare them with healthy postmenopausal subjects.

methodsBMD was assessed at the lumbar spine, femoral sites, distal radius, and total forearm using dual-energy X-ray absorptiometry (DXA); TBS was measured based on DXA images using the software at the same region of interest as the BMD measurements; geometric assessment at the proximal femur was performed by the HSA program.

resultsA total of 348 ambulatory type-2 diabetic postmenopausal women and 539 healthy postmenopausal women were enrolled. TBS and BMD at the distal radius and total forearm were significantly (P value < 0.05) lower in cases compared to controls after age and body mass index (BMI) adjustment. In addition, degraded bone microarchitecture was significantly (P value < 0.05) more prevalent in diabetic subjects than in non-diabetic controls after adjusting for age and BMI. A number of geometric indices of the proximal hip were significantly lower in the controls than in those with diabetes (P-value < 0.05).

conclusionThis study may highlight the utility of the TBS and BMD at the distal radius and total forearm in subjects with type-2 diabetes mellitus, where the BMD at central sites may not adequately predict fracture risk.

Indexed as

Diabetes Mellitus, Type 2Osteoporosis, PostmenopausalOsteoporotic FracturesAbsorptiometry, PhotonBone DensityCancellous BoneCross-Sectional StudiesFemaleHumansIranLumbar VertebraePostmenopauseBone mineral densityDiabetes mellitus type 2Fracture riskHip structural analysisPost-menopausal osteoporosisTrabecular bone score

Identifiers

PMID37454358
OpenAlexW4384471252

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.