Evidence map›Paper›PMID 37454253›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2023

Analgesic efficacy of median nerve stimulation in mice with chemotherapy-induced peripheral neuropathymodulation of brain-derived neurotrophic factor expression.

Dong-Wook Kang, Jae-Gyun Choi, Hee Ju Song, Jaehyuk Kim, Miae Lee, Taehee Kim, Suk-Yun Kang, Yeonhee Ryu, Hwa Seung Yoo, Jin Sun Lee and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Dong-Wook KangDepartment of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University, Daejeon 35015, Republic of Korea.
Jae-Gyun ChoiDepartment of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University, Daejeon 35015, Republic of Korea.
Hee Ju SongDepartment of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University, Daejeon 35015, Republic of Korea.
Jaehyuk KimDepartment of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University, Daejeon 35015, Republic of Korea.
Miae LeeDepartment of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University, Daejeon 35015, Republic of Korea.
Taehee KimDepartment of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University, Daejeon 35015, Republic of Korea.
Suk-Yun KangKM Fundamental Research Division Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
Yeonhee RyuKM Fundamental Research Division Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
Hwa Seung YooEast-West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University, Daejeon 35234, Republic of Korea.
Jin Sun LeeDepartment of Surgery, Chungnam National University Hospital, Daejeon 35015, Republic of Korea.
Jin Bong ParkLaboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
Sang Do LeeDepartment of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University, Daejeon 35015, Republic of Korea.
Hyun-Woo KimDepartment of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University, Daejeon 35015, Republic of Korea.
Chungnam National University Hospital · KR

Funding

NIEHS NIH HHS 27398C0007
6 · The paper itself

Abstract

objectiveChemotherapeutic agents such as docetaxel (DTX) can trigger chemotherapy-induced peripheral neuropathy (CIPN), which is characterized by unbearable pain. This study was designed to investigate the analgesic effect and related neuronal mechanism of low-frequency median nerve stimulation (LFMNS) on DTX-induced tactile hypersensitivity in mice.

methodsTo produce CIPN, DTX was administered intraperitoneally 4 times, once every 2 d, to male ICR mice. LFMNS was performed on the wrist area, and the pain response was measured using von Frey filaments on both hind paws. Western blot and immunofluorescence staining were performed using dorsal root ganglion and spinal cord samples to measure the expression of brain-derived neurotrophic factor (BDNF).

resultsRepeated LFMNS significantly attenuated the DTX-induced abnormal sensory response and suppressed the enhanced expression of BDNF in the DRG neurons and spinal dorsal area.

conclusionsLFMNS might be an effective non-pharmaceutical option for treating patients suffering from CIPN regulating the expression of peripheral and central BDNF.

Indexed as

Antineoplastic AgentsPeripheral Nervous System DiseasesAnalgesicsAnimalsBrain-Derived Neurotrophic FactorMaleMedian NerveMiceMice, Inbred ICRPainRatsRats, Sprague-DawleyAnalgesicsAntineoplastic AgentsBrain-Derived Neurotrophic Factoranalgesiabrain-derived neurotrophic factorchemotherapy-induced peripheral neuropathydocetaxelnerve stimulation

Identifiers

PMID37454253
PMCPMC10320447
OpenAlexW4384466949

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.