ArticleCommunications biology2023
The cerebellum contributes to generalized seizures by altering activity in the ventral posteromedial nucleus.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- miR-9-5p is Downregulated in Serum Extracellular Vesicles of Patients Treated with Biperiden After Traumatic Brain Injury.Molecular neurobiology · 2024Trial
- Histological aging signatures for monitoring tissue-specific aging and disease.Nature medicine · 2026Article
- Cerebellar Electrical Activity as a Marker for Predicting Brain Health and Disease: A Review.Brain sciences · 2026Review
- Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex.eLife · 2025Article
- Brain-wide mapping of developmental trajectories of cerebellar efferent projections.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex.bioRxiv : the preprint server for biology · 2025Article
- Sensory Afferent Neural Circuits Mediate Electroacupuncture to Improve Swallowing Function in a Post-Stroke Dysphagia Mouse Model.CNS neuroscience & therapeutics · 2025Article
- Molecular Mechanisms Underlying the Generation of Absence Seizures: Identification of Potential Targets for Therapeutic Intervention.International journal of molecular sciences · 2024Review
- Enhancing Flexible Neural Probe Performance via Platinum Deposition: Impedance Stability under Various Conditions and In Vivo Neural Signal Monitoring.Micromachines · 2024Article
- Sensorimotor regulation of facial expression - An untouched frontier.Neuroscience and biobehavioral reviews · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
Thalamo-cortical networks are central to seizures, yet it is unclear how these circuits initiate seizures. We test whether a facial region of the thalamus, the ventral posteromedial nucleus (VPM), is a source of generalized, convulsive motor seizures and if convergent VPM input drives the behavior. To address this question, we devise an in vivo optogenetic mouse model to elicit convulsive motor seizures by driving these inputs and perform single-unit recordings during awake, convulsive seizures to define the local activity of thalamic neurons before, during, and after seizure onset. We find dynamic activity with biphasic properties, raising the possibility that heterogenous activity promotes seizures. Virus tracing identifies cerebellar and cerebral cortical afferents as robust contributors to the seizures. Of these inputs, only microinfusion of lidocaine into the cerebellar nuclei blocks seizure initiation. Our data reveal the VPM as a source of generalized convulsive seizures, with cerebellar input providing critical signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.