ArticleJournal of orthopaedic surgery and research2023
Osteoarthritis and sarcopenia-related traits: the cross-sectional study from NHANES 2011-2014 and Mendelian randomization study.
Article in Journal of orthopaedic surgery and research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Using Mendelian randomization analyses in osteoarthritis: state of art and future perspectives.Annals of medicine · 2025Pooled it
- Semaglutide targets muscle mitochondria to regulate glutamine metabolism and treat osteoarthritis.iScience · 2026Article
- Longitudinal trends and causal relationships of depression, anxiety, and sleep quality among MSM newly diagnosed with HIV.Social psychiatry and psychiatric epidemiology · 2026Article
- The association between sarcopenia, sedentary behavior, and the motor cognitive risk syndrome: A Mendelian randomization study.Medicine · 2026Article
- Association between the sarcopenia index and osteoarthritis: a cross-sectional and longitudinal study.European journal of medical research · 2026Article
- Sarcopenia severity and its prognostic value for structural and functional progression in elderly patients with knee osteoarthritis: a 24-month retrospective cohort study.American journal of translational research · 2026Article
- Article
- The association between arthritis and insomnia risk: Evidence from NHANES 2005 to 2008 and Mendelian randomization (MR) analyses.Medicine · 2025Article
- C-reactive protein as a mediator in the link between cardiometabolic index and osteoarthritis: insights from NHANES 2001-2010.Lipids in health and disease · 2025Article
- Exploring the link between osteosarcopenia and osteoarthritis in prediabetic adults using NHANES data.Scientific reports · 2025Article
- Arthritis increases the risk of prostate cancer: Results from the National Health and Nutrition Examination Survey 2005-2018 and two-sample Mendelian randomization analysis.Investigative and clinical urology · 2025Article
- Association between lean body mass and osteoarthritis: a cross-sectional study from the NHANES 2007-2018.Scientific reports · 2025Article
- Association between sarcopenia and the prevalence of gallstone in US adults: a cross-sectional analysis of NHANES.BMC gastroenterology · 2025Article
- New insights into the association between arthritis and overactive bladder in NHANES 2005-2020.Scientific reports · 2025Article
- Complement 3 and 4 impact in osteoarthritis.Biomarkers in medicine · 2025Article
- Impact of Resistance Exercise and Nitrate Supplementation on Muscle Function and Clinical Outcomes After Knee Osteoarthritis Surgery in Middle-Aged Women with Sarcopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.Journal of clinical medicine · 2025Article
- Association between geriatric nutritional risk index and osteoarthritis in aged person over 60: data from NHANES 2005-2018.Frontiers in medicine · 2025Article
- Sarcopenia prediction model based on machine learning and SHAP values for community-based older adults with cardiovascular disease in China.Frontiers in public health · 2025Article
- Kashin-Beck Disease: A Risk Factor for Sarcopenia and Its Interaction with Selenium.Nutrients · 2024Article
- Association of sarcopenia and its prognostic value in symptomatic knee osteoarthritis among older people in China: the first longitudinal evidence from CHARLS.BMC geriatrics · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOsteoarthritis (OA) and sarcopenia are common musculoskeletal disorders in the aged population, and a growing body of evidence indicated that they mutually influence one another. Nevertheless, there was still substantial controversy and uncertainty about the causal relationship between sarcopenia and OA. We explored the complex association between sarcopenia-related traits and OA using cross-sectional analysis and Mendelian randomization (MR).
methodsThe cross-sectional study used the data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Weighted multivariable-adjusted logistic regression and subgroup analyses were used to evaluate the correlation between sarcopenia, grip, appendicular lean mass (ALM) and the risk of OA. Then, we further performed MR analysis to examine the causal effect of sarcopenia-related traits (grip strength, ALM) on OA. Instrumental variables for grip strength and ALM were from the UK Biobank, and the summary-level data for OA was derived from the Genetics of Osteoarthritis (GO) Consortium GWAS (n = 826,690).
resultsIn this cross-sectional analysis, we observed that sarcopenia, grip were significantly linked with the risk of OA (OR 1.607, 95% CI 1.233-2.094, P < 0.001), (OR 0.972, 95% CI 0.964-0.979, P < 0.001). According to subgroup analyses stratified by gender, body mass index (BMI), and age, the significant positive relationship between sarcopenia and OA remained in males, females, the age (46-59 years) group, and the BMI (18.5-24.9 kg/m
conclusionsOur research provided evidence that sarcopenia is correlated with an increased risk of OA, and there was a protective impact of genetically predicted grip strength on OA. These findings needed to be verified in further prospective cohort studies with a large sample size.
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