Evidence map›Paper›PMID 37454174›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2023

Neonatal brain MRI and short-term outcomes after acute provoked seizures.

Yi Li, Aaron Scheffler, Anthony James Barkovich, Taeun Chang, Catherine J Chu, Shavonne L Massey, Nicholas S Abend, Monica E Lemmon, Cameron Thomas, Adam Numis and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Status epilepticus in the neonate.BMJ paediatrics open · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yi LiDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA. yi.li@ucsf.edu.ORCID 0000-0001-8535-2168
Aaron SchefflerDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Anthony James BarkovichDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Taeun ChangDepartment of Neurology, Children's National Hospital, George Washington University School of Medicine, Washington, DC, USA.ORCID 0000-0002-1797-8449
Catherine J ChuDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Shavonne L MasseyDepartments of Neurology and Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Nicholas S AbendDepartments of Neurology and Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Monica E LemmonDepartment of Pediatrics and Population Health Sciences, Duke University School of Medicine, Durham, NC, USA.
Cameron ThomasDepartment of Pediatrics, University of Cincinnati and Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Adam NumisDepartment of Neurology and Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1594-9812
Linda S FranckDepartment of Family Health Care Nursing, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-4291-9181
Elizabeth RogersDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA, USA.
Andrew CallenDepartment of Radiology, University of Colorado Denver School of Medicine, Denver, CO, USA.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Renée A ShellhaasDivision of Pediatric Neurology, Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
Hannah C GlassDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe investigated how diagnosis and injury location on neonatal brain MRI following onset of acute provoked seizures was associated with short term outcome. STUDY

designA multicenter cohort of neonates with acute provoked seizures enrolled in the Neonatal Seizure Registry. MRIs were centrally evaluated by a neuroradiologist for location of injury and radiologic diagnosis. Clinical outcomes were determined by chart review. Multivariate logistic regression was used to examine the association between MRI findings and outcomes.

resultsAmong 236 newborns with MRI at median age 4 days (IQR 3-8), 91% had abnormal MRI. Radiologic diagnoses of intracranial hemorrhage (OR 3.2 [1.6-6.5], p < 0.001) and hypoxic-ischemic encephalopathy (OR 2.7 [1.4-5.4], p < 0.003) were associated with high seizure burden. Radiologic signs of intracranial infection were associated with abnormal neurologic examination at discharge (OR 3.9 [1.3-11.6], p < 0.01).

conclusionFindings on initial MRI can help with expectant counseling on short-term outcomes following acute provoked neonatal seizures.

Indexed as

EpilepsyHypoxia-Ischemia, BrainInfant, Newborn, DiseasesBrainElectroencephalographyHumansInfant, NewbornMagnetic Resonance ImagingNeuroimagingSeizures

Identifiers

PMID37454174
PMCPMC10615741

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.