Evidence map›Paper›PMID 37453512›Full record

ArticleDiabetes research and clinical practice2023

Glucagon prescribing and prevention of hospitalization for hypoglycemia in a large health system.

Joseph R Herges, Jordan D Haag, Kimberly A Kosloski Tarpenning, Kristin C Mara, Rozalina G McCoy

Open access · greenAbstract read
In one paragraph

Article in Diabetes research and clinical practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Joseph R HergesDepartment of Pharmacy, Mayo Clinic, Rochester, MN, United States. Electronic address: Herges.Joseph@mayo.edu.
Jordan D HaagDepartment of Pharmacy, Mayo Clinic, Rochester, MN, United States. Electronic address: Haag.Jordan@mayo.edu.
Kimberly A Kosloski TarpenningDepartment of Pharmacy, Mayo Clinic Health System, Southeast Minnesota region, Owatonna, MN, United States. Electronic address: Tarpenning.Kimberly@mayo.edu.
Kristin C MaraDivision of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, United States. Electronic address: Mara.Kristin@mayo.edu.
Rozalina G McCoyDivision of Community Internal Medicine, Geriatrics, and Palliative Care, Mayo Clinic, Rochester, MN, United States. Electronic address: McCoy.Rozalina@mayo.edu.
Mayo Clinic · USMayo Clinic Health System · USMayo Clinic in Arizona · US

Funding

Predicting the Risk of Severe Hypoglycemic and Hyperglycemic Events in Adults with DiabetesK23DK114497 · NIDDK · MAYO CLINIC ROCHESTER · PI MCCOY, ROZALINA GRUBINA · 2017 to 2021
$846k
NIDDK NIH HHS K23 DK114497
6 · The paper itself

Abstract

aimsTo examine glucagon prescribing trends among patients at high risk of severe hypoglycemia and assess if a glucagon prescription is associated with lower rates of severe hypoglycemia requiring hospital care.

methodsRetrospective analysis of electronic health records from a large integrated healthcare system between May 2019 and August 2021. We included adults (≥18 years) with type 1 diabetes or with type 2 diabetes treated with short-acting insulin and/or recent history of hypoglycemia-related emergency department visit or hospitalization. We calculated rates of glucagon prescribing overall and by patient characteristics. We then matched 1:1 those who were and were not prescribed glucagon and assessed subsequent hypoglycemia-related hospitalization.

resultsOf 9,200 high risk adults, 2063 (22.4%) were prescribed glucagon. Among patients more likely to be prescribed glucagon were those younger, female, White, living in urban areas, with prior severe hypoglycemia, and with a recent endocrinology specialist visit. In the matched cohort (N = 1707 per arm), 62 prescribed glucagon and 33 not prescribed glucagon were hospitalized for hypoglycemia (adjusted incidence rate ratio 1.71, 95% CI 1.10-2.66; P = 0.018).

conclusionGlucagon prescribing was infrequent with significant racial and rural disparities. Patients with glucagon prescriptions did not have lower rates of hospitalization for hypoglycemia.

Indexed as

Diabetes Mellitus, Type 2HypoglycemiaAdultFemaleGlucagonHospitalizationHumansHypoglycemic AgentsRetrospective StudiesGlucagonHypoglycemic AgentsDiabetesGlucagonHospitalizationHypoglycemia

Identifiers

PMID37453512
PMCPMC10527928
OpenAlexW4384156869

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.