Evidence map›Paper›PMID 37453427›Full record

ArticleCurrent biology : CB2023

SPE-51, a sperm-secreted protein with an immunoglobulin-like domain, is required for fertilization in C. elegans.

Xue Mei, Katherine A Maniates, A'maya Looper, Amber R Krauchunas, Marina Druzhinina, Sunny Dharia, Julie Ni, Gunasekaran Singaravelu, Sam Guoping Gu, Diane C Shakes and 2 more

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Characterization ofbioRxiv : the preprint server for biology · 2026
    Article
  3. UtilizingJournal of developmental biology · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Xue MeiWaksman Institute and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA; Department of Biological Sciences, St. John's University, Jamaica, NY 11439, USA. Electronic address: meix@stjohns.edu.
Katherine A ManiatesWaksman Institute and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA.
A'maya LooperDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Amber R KrauchunasDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Marina DruzhininaWaksman Institute and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA.
Sunny DhariaWaksman Institute and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA.
Julie NiDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.
Gunasekaran SingaraveluWaksman Institute and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA.
Sam Guoping GuDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.
Diane C ShakesDepartment of Biology, College of William and Mary, Williamsburg, VA 23187, USA.
Barth D GrantDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.
Andrew W SingsonWaksman Institute and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: singson@waksman.rutgers.edu.
Rutgers, The State University of New Jersey · USUniversity of Delaware · USWilliam & Mary · US

Funding

IRACDA at Rutgers: INSPIRE Postdoctoral Training ProgramK12GM093854 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Detlev Boison, Gary A. Brewer · 2010 to 2026
$14.7M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
[RNW] - Gamete Interactions in Caenorhabditis elegansR01HD054681 · NICHD · RUTGERS, THE STATE UNIV OF N.J. · PI ANDREW W. SINGSON · 2008 to 2026
$5.3M
RNA-mediated Chromatin Regulation and Epigenetic Inheritance in C. elegansR01GM111752 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI GU, GUOPING · 2014 to 2023
$3.1M
Molecular regulation of endosome fission during endocytic recyclingR01GM135326 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI Barth Demian Grant · 2020 to 2026
$2.6M
Coordinating the Developmental and Cell Cycle Programs of SpermatogenesisR15GM096309 · NIGMS · COLLEGE OF WILLIAM AND MARY · PI SHAKES, DIANE CAROL · 2011 to 2011
$279k
NICHD NIH HHS R01 HD054681NIGMS NIH HHS K12 GM093854NIGMS NIH HHS R01 GM111752NIGMS NIH HHS R01 GM135326NIGMS NIH HHS R15 GM096309NIH HHS P40 OD010440
6 · The paper itself

Abstract

Fertilization is a fundamental process in sexual reproduction during which gametes fuse to combine their genetic material and start the next generation in their life cycle. Fertilization involves species-specific recognition, adhesion, and fusion between the gametes.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAmino Acid SequenceAnimalsFertilizationImmunoglobulin DomainsMaleMammalsMembrane ProteinsSemenSpermatozoaSperm-Ovum InteractionsSperm ProteinsCaenorhabditis elegans ProteinsMembrane ProteinsSperm ProteinsC. elegansfertilizationfertilization synapsegamete interactionimmunoglobulinoocytesecreted proteinsperm

Identifiers

PMID37453427
PMCPMC10528068
OpenAlexW4384301751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.