Evidence map›Paper›PMID 37453426›Full record

ArticleCurrent biology : CB2023

The EGF-motif-containing protein SPE-36 is a secreted sperm protein required for fertilization in C. elegans.

Amber R Krauchunas, Matthew R Marcello, A'Maya Looper, Xue Mei, Emily Putiri, Gunasekaran Singaravelu, Iqra I Ahmed, Andrew Singson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Characterization ofbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. UtilizingJournal of developmental biology · 2025
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Amber R KrauchunasWaksman Institute and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA; Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA. Electronic address: arkrauch@udel.edu.
Matthew R MarcelloDepartment of Biology, Pace University, New York, NY 11231, USA.
A'Maya LooperDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Xue MeiWaksman Institute and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA.
Emily PutiriWaksman Institute and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA.
Gunasekaran SingaraveluWaksman Institute and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA.
Iqra I AhmedDepartment of Biology, Pace University, New York, NY 11231, USA.
Andrew SingsonWaksman Institute and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA.
Rutgers, The State University of New Jersey · USPace University · USUniversity of Delaware · US

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI MELINDA K DUNCAN · 2012 to 2026
$67.2M
Understanding synovial macrophage inflamm-aging within osteoarthritisP20GM139760 · NIGMS · UNIVERSITY OF DELAWARE · PI DAWN M ELLIOTT · 2021 to 2026
$19.1M
IRACDA at Rutgers: INSPIRE Postdoctoral Training ProgramK12GM093854 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Detlev Boison, Gary A. Brewer · 2010 to 2026
$14.7M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
[RNW] - Gamete Interactions in Caenorhabditis elegansR01HD054681 · NICHD · RUTGERS, THE STATE UNIV OF N.J. · PI ANDREW W. SINGSON · 2008 to 2026
$5.3M
Spinning Disk Confocal and Single Molecule Localization MicroscopeS10OD030321 · OD · UNIVERSITY OF DELAWARE · PI CAPLAN, JEFFREY L · 2021 to 2021
$562k
NICHD NIH HHS R01 HD054681NIGMS NIH HHS K12 GM093854NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM139760NIH HHS P40 OD010440NIH HHS S10 OD030321
6 · The paper itself

Abstract

Identified through forward genetics, spe-9 was the first gene to be identified in C. elegans as necessary for fertilization.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAnimalsEpidermal Growth FactorFertilizationMaleMammalsMembrane ProteinsSemenSpermatozoaSperm ProteinsCaenorhabditis elegans ProteinsEpidermal Growth FactorMembrane ProteinsSperm ProteinsC. elegansfertilizationfertilization synapseoocytesecreted proteinspe-36sperm

Identifiers

PMID37453426
PMCPMC10529607
OpenAlexW4384344044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.